NDLI: Outer retinal abnormalities associated with inner retinal pathology in nonglaucomatous and glaucomatous optic neuropathies

Content Provider	PubMed Central
Author	Werner, J. S. Keltner, J. L. Zawadzki, R. J. Choi, S. S.
Copyright Year	2011
Abstract	Inner and outer retinal morphology were quantified in vivo for 6 nonglaucomatous and 10 glaucomatous optic neuropathy patients. Custom, ultrahigh-resolution imaging modalities were used to evaluate segmented retinal layer thickness in 3D volumes (Fourier-domain optical coherence tomography), cone photoreceptor density (adaptive optics fundus camera), and the length of inner and outer segments of cone photoreceptors (adaptive optics–optical coherence tomography). Quantitative comparisons were made with age-matched controls, or by comparing affected and nonaffected retinal areas defined by changes in visual fields. The integrity of outer retinal layers on optical coherence tomography B-scans and density of cone photoreceptors were correlated with visual field sensitivity at corresponding retinal locations following reductions in inner retinal thickness. The photoreceptor outer segments were shorter and exhibited greater variability in retinal areas associated with visual field losses compared with normal or less affected areas of the same patient's visual field. These results demonstrate that nonglaucomatous and glaucomatous optic neuropathies are associated with outer retinal changes following long-term inner retinal pathology.
Related Links	http://dx.doi.org/10.1038/eye.2010.218
Ending Page	289
Page Count	11
Starting Page	279
File Format	PDF
ISSN	0950222X
e-ISSN	14765454
Journal	Eye
Issue Number	3
Volume Number	25
Language	English
Publisher	Nature Publishing Group
Publisher Date	2011-03-01
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Ophthalmology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Arts and Humanities Sensory Systems

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Outer retinal abnormalities associated with inner retinal pathology in nonglaucomatous and glaucomatous optic neuropathies

Inner and Outer Retinal Changes in Retinal Degenerations Associated With ABCA4 Mutations

Nonglaucomatous optic neuropathies in Port Harcourt

Retinal detachment associated with optic disc colobomas and morning glory syndrome

Calcium overload is associated with lipofuscin formation in human retinal pigment epithelial cells fed with photoreceptor outer segments

Hereditary optic neuropathies

Optical coherence tomography shows retinal abnormalities associated with optic nerve disease

Treatment strategies for inherited optic neuropathies: past, present and future

Anterior optic nerve microvascular changes in human glaucomatous optic neuropathy

Outer retinal abnormalities associated with inner retinal pathology in nonglaucomatous and glaucomatous optic neuropathies

Similar Documents

Outer retinal abnormalities associated with inner retinal pathology in nonglaucomatous and glaucomatous optic neuropathies

Inner and Outer Retinal Changes in Retinal Degenerations Associated With ABCA4 Mutations

Nonglaucomatous optic neuropathies in Port Harcourt

Retinal detachment associated with optic disc colobomas and morning glory syndrome

Calcium overload is associated with lipofuscin formation in human retinal pigment epithelial cells fed with photoreceptor outer segments

Hereditary optic neuropathies

Optical coherence tomography shows retinal abnormalities associated with optic nerve disease

Treatment strategies for inherited optic neuropathies: past, present and future

Anterior optic nerve microvascular changes in human glaucomatous optic neuropathy

Outer retinal abnormalities associated with inner retinal pathology in nonglaucomatous and glaucomatous optic neuropathies