NDLI: The endogenous cannabinoid anandamide shares discriminative stimulus effects with Δ9-tetrahydrocannabinol in fatty acid amide hydrolase knockout mice

Content Provider	PubMed Central
Author	Matthew, Walentiny D. Gamage, Thomas F. Warner, Jonathan A. Nguyen, Thanh K. Grainger, Darren B. Wiley, Jenny L. Vann, Robert E.
Copyright Year	2010
Abstract	The endogenous cannabinoid system has been noted for its therapeutic potential, as well as the psychoactivity of cannabinoids such as Δ9-tetrahydrocannabinol (THC). However, less is known about the psychoactivity of anandamide (AEA), an endocannabinoid ligand. Thus, the goals of this study were to establish AEA as a discriminative stimulus in transgenic mice lacking fatty acid amide hydrolase (i.e., FAAH −/− mice unable to rapidly metabolize AEA), evaluate whether THC or oleamide, a fatty acid amide, produced AEA-like responding, and assess for CB1 mediation of AEA’s discriminative stimulus. Mice readily discriminated between 6 mg/kg AEA and vehicle in a two-lever drug discrimination task. AEA dose-dependently generalized to itself. THC elicited full AEA-like responding, whereas oleamide failed to substitute. The CB1 antagonist rimonabant attenuated AEA- and THC-induced AEA-appropriate responding, demonstrating CB1 mediation of AEA’s discriminative stimulus. These findings suggest that, in the absence of FAAH, AEA produces intoxication comparable to THC, and consequently to marijuana.
Related Links	http://dx.doi.org/10.1016/j.ejphar.2011.01.056
Ending Page	67
Page Count	5
Starting Page	63
File Format	PDF
ISSN	00142999
e-ISSN	18790712
Journal	European journal of pharmacology
Issue Number	1-3
Volume Number	656
Language	English
Publisher Date	2011-04-01
Access Restriction	Open
Subject Keyword	Pharmacology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pharmacology

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Simultaneous inhibition of fatty acid amide hydrolase and monoacylglycerol lipase shares discriminative stimulus effects with Δ9-tetrahydrocannabinol in mice.

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The endogenous cannabinoid anandamide shares discriminative stimulus effects with Δ9-tetrahydrocannabinol in fatty acid amide hydrolase knockout mice

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