NDLI: Enhanced Integration of Newborn Neurons after Neonatal Insults

Content Provider	PubMed Central
Author	Pugh, Phyllis Elena, Adlaf Zhao, Chuan-sheng Markwardt, Sean Gavin, Cristin Jacques, Wadiche Linda, Overstreet-wadiche
Copyright Year	2011
Abstract	The production and integration of adult-generated neurons in the dentate gyrus is dramatically perturbed by a variety of pathological insults, including repetitive seizures and hypoxia/ischemia. Less is known about how insults affect early postnatal neurogenesis, during the developmental period when the majority of dentate neurons are produced. Here we tested how single episodes of hypoxia or chemically induced seizure activity in postnatal day 10 mice alter granule cell production and integration. Although neither insult was sufficient to alter the number of newborn neurons nor the population of proliferating cells, both treatments increased the dendritic complexity of newborn granule cells that were born around the time of the insult. Surprisingly, only the dendritic enhancement caused by hypoxia was associated with increased synaptic integration. These results suggest that alterations in dendritic integration can be dissociated from altered neural production and that integration appears to have a lower threshold for perturbation. Furthermore, newborn neurons in adult mice that experienced neonatal hypoxia had reduced dendritic length while having no alterations in number. Together these results suggest that single insults during the neonatal period can have both long- and short-term consequences for neuronal maturation.
Related Links	http://dx.doi.org/10.3389/fnins.2011.00045
Starting Page	45
File Format	PDF
ISSN	1662453X
e-ISSN	1662453X
Journal	Frontiers in Neuroscience
Volume Number	5
Language	English
Publisher	Frontiers Research Foundation
Publisher Date	2011-03-30
Access Restriction	Open
Rights Holder	Frontiers Research Foundation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Decreased survival of newborn neurons in the dorsal hippocampus after neonatal LPS exposure in mice ☆

Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults

Long-term neurodevelopmental outcomes after intrauterine and neonatal insults: a systematic review

Functional Integration of Adult-Born Hippocampal Neurons after Traumatic Brain Injury 1,2,3

Is integration and survival of newborn neurons the bottleneck for effective neural repair by endogenous neural precursor cells?

Antenatal Insults Modify Newborn Olfactory Function By Nitric Oxide Produced From Neuronal Nitric Oxide Synthase

Recruitment of hypothalamic orexin neurons after formalin injections in adult male rats exposed to a neonatal immune challenge

Temporomandibular joint-evoked responses by spinomedullary neurons and masseter muscle are enhanced after repeated psychophysical stress

Functional integration of new neurons into hippocampal networks and post-stroke co-morbidities following neonatal stroke in mice

Enhanced Integration of Newborn Neurons after Neonatal Insults

Similar Documents

Decreased survival of newborn neurons in the dorsal hippocampus after neonatal LPS exposure in mice ☆

Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults

Long-term neurodevelopmental outcomes after intrauterine and neonatal insults: a systematic review

Functional Integration of Adult-Born Hippocampal Neurons after Traumatic Brain Injury 1,2,3

Is integration and survival of newborn neurons the bottleneck for effective neural repair by endogenous neural precursor cells?

Antenatal Insults Modify Newborn Olfactory Function By Nitric Oxide Produced From Neuronal Nitric Oxide Synthase

Recruitment of hypothalamic orexin neurons after formalin injections in adult male rats exposed to a neonatal immune challenge

Temporomandibular joint-evoked responses by spinomedullary neurons and masseter muscle are enhanced after repeated psychophysical stress

Functional integration of new neurons into hippocampal networks and post-stroke co-morbidities following neonatal stroke in mice

Enhanced Integration of Newborn Neurons after Neonatal Insults