NDLI: Expression of p16INK4a prevents cancer and promotes aging in lymphocytes

Content Provider	PubMed Central
Author	Liu, Yan Johnson, Soren M. Fedoriw, Yuri Rogers, Arlin B. Yuan, Hong Krishnamurthy, Janakiraman Sharpless, Norman E.
Abstract	Previous authors have suggested that tumor suppressor expression promotes aging while preventing cancer, but direct experimental support for this cancer-aging hypothesis has been elusive. Here, by using somatic, tissue-specific inactivation of the p16INK4a tumor suppressor in murine T- or B-lymphoid progenitors, we report that ablation of p16INK4a can either rescue aging or promote cancer in a lineage-specific manner. Deletion of p16INK4a in the T lineage ameliorated several aging phenotypes, including thymic involution, decreased production of naive T cells, reduction in homeostatic T-cell proliferation, and attenuation of antigen-specific immune responses. Increased T-cell neoplasia was not observed with somatic p16INK4a inactivation in T cells. In contrast, B lineage–specific ablation of p16INK4a was associated with a markedly increased incidence of systemic, high-grade B-cell neoplasms, which limited studies of the effects of somatic p16INK4a ablation on B-cell aging. Together, these data show that expression of p16INK4a can promote aging and prevent cancer in related lymphoid progeny of a common stem cell.
Related Links	http://dx.doi.org/10.1182/blood-2010-09-304402
Starting Page	3257
File Format	PDF
ISSN	15280020
e-ISSN	15280020
Journal	Blood
Issue Number	12
Volume Number	117
Language	English
Publisher	American Society of Hematology
Publisher Date	2011-03-24
Access Restriction	Open
Rights Holder	American Society of Hematology
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Hematology Biochemistry Immunology

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