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| Content Provider | PubMed Central |
|---|---|
| Author | Pruvot, Benoist Jacquel, Arnaud Droin, Nathalie Patrick, Auberger Didier, Bouscary Tamburini, Jérome Muller, Marc Fontenay, Michaela Chluba, Johanna Eric, Solary |
| Abstract | Zebrafish were proposed as an alternative to mammalian models to assess the efficacy and toxicity of antileukemic drugs. Due to the limited number of transgenic zebrafish leukemia models, we explored human leukemic cell xenograft in zebrafish embryos. Human leukemic cell lines and blast cells sorted from patients with acute myelogenous leukemia were injected 48 hours post-fertilization and remained in the circulation of zebrafish embryos for several days without affecting their development. Imatinib and oxaphorines did not demonstrate any toxicity on normal zebrafish embryos and decreased the leukemic burden in animals xenografted with sensitive leukemic cell lines. Two other molecules, all-trans retinoic acid and the translation inhibitor 4EGI-1, demonstrated teratogenic effects at concentrations shown to be efficient in vitro, which precluded investigation of their antileukemic activity in such models. Altogether, xenografted leukemic cells in zebrafish embryos are a pharmacologically relevant model for screening non-teratogenic drugs. |
| Related Links | http://dx.doi.org/10.3324/haematol.2010.031401 |
| Ending Page | 616 |
| Page Count | 5 |
| Starting Page | 612 |
| File Format | |
| ISSN | 03906078 |
| e-ISSN | 15928721 |
| Journal | Haematologica |
| Issue Number | 4 |
| Volume Number | 96 |
| Language | English |
| Publisher | Ferrata Storti Foundation |
| Publisher Date | 2011-04-01 |
| Access Restriction | Open |
| Rights Holder | Ferrata Storti Foundation |
| Subject Keyword | Hematology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology |
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