NDLI: The IFITM Proteins Inhibit HIV-1 Infection▿ †

Content Provider	PubMed Central
Author	Lu, Jennifer Pan, Qinghua Rong, Liwei Liu, Shan-lu Liang, Chen
Copyright Year	2011
Abstract	Type I interferon protects cells from virus infection through the induction of a group of genes collectively named interferon-stimulated genes (ISGs). In this study, we utilized short hairpin RNA (shRNA) to deplete ISGs in SupT1 cells in order to identify ISGs that suppress the production of human immunodeficiency virus type 1 (HIV-1). Among the ISG candidates thus identified were interferon-induced transmembrane (IFITM) proteins, including IFITM1, IFITM2, and IFITM3, that potently inhibit HIV-1 replication at least partially through interfering with virus entry. Further mutagenesis analysis shows that the intracellular region, rather than the N- and C-terminal extracellular domains, is essential for the antiviral activity of IFITM1. Altogether, these data suggest that the IFITM proteins serve as important components of the innate immune system to restrict HIV-1 infection.
Related Links	http://dx.doi.org/10.1128/jvi.01531-10
Ending Page	2137
Page Count	12
Starting Page	2126
File Format	PDF
ISSN	0022538X
e-ISSN	10985514
Journal	Journal of Virology
Issue Number	5
Volume Number	85
Language	English
Publisher	American Society for Microbiology (ASM)
Publisher Date	2011-03-01
Access Restriction	Open
Rights Holder	American Society for Microbiology (ASM)
Subject Keyword	Immunology Virology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology Insect Science

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