NDLI: Distinct Host Species Correlate with Anaplasma phagocytophilum ankA Gene Clusters ▿ †

Content Provider	PubMed Central
Author	Scharf, Wiebke Schauer, Sonja Felix, Freyburger Petrovec, Miroslav Daniel, Schaarschmidt-kiener Liebisch, Gabriele Runge, Martin Ganter, Martin Kehl, Alexandra Dumler, J. Stephen Garcia Perez, Ana L. Jensen, Jennifer Volker, Fingerle Meli, Marina L. Armin, Ensser Stuen, Snorre Von, Loewenich Friederike D.
Copyright Year	2011
Abstract	Anaplasma phagocytophilum is a Gram-negative, tick-transmitted, obligate intracellular bacterium that elicits acute febrile diseases in humans and domestic animals. In contrast to the United States, human granulocytic anaplasmosis seems to be a rare disease in Europe despite the initial recognition of A. phagocytophilum as the causative agent of tick-borne fever in European sheep and cattle. Considerable strain variation has been suggested to occur within this species, because isolates from humans and animals differed in their pathogenicity for heterologous hosts. In order to explain host preference and epidemiological diversity, molecular characterization of A. phagocytophilum strains has been undertaken. Most often the 16S rRNA gene was used, but it might be not informative enough to delineate distinct genotypes of A. phagocytophilum. Previously, we have shown that A. phagocytophilum strains infecting Ixodes ricinus ticks are highly diverse in their ankA genes. Therefore, we sequenced the 16S rRNA and ankA genes of 194 A. phagocytophilum strains from humans and several animal species. Whereas the phylogenetic analysis using 16S rRNA gene sequences was not meaningful, we showed that distinct host species correlate with A. phagocytophilum ankA gene clusters.
Related Links	http://dx.doi.org/10.1128/jcm.02051-10
Ending Page	796
Page Count	7
Starting Page	790
File Format	PDF
ISSN	00951137
e-ISSN	1098660X
Journal	Journal of Clinical Microbiology
Issue Number	3
Volume Number	49
Language	English
Publisher	American Society for Microbiology
Publisher Date	2011-03-01
Access Restriction	Open
Rights Holder	American Society for Microbiology
Subject Keyword	Microbiology (medical) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Microbiology (medical)

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Genome-Wide Anaplasma phagocytophilum AnkA-DNA Interactions Are Enriched in Intergenic Regions and Gene Promoters and Correlate with Infection-Induced Differential Gene Expression

High Diversity of ankA Sequences of Anaplasma phagocytophilum among Ixodes ricinus Ticks in Germany

Contribution of Polymorphisms in ankA, gltA, and groESL in Defining Genetic Variants of Anaplasma phagocytophilum ▿ †

Anaplasma phagocytophilum Ankyrin A Protein (AnkA) Enters the Nucleus Using an Importin-β-, RanGTP-Dependent Mechanism

Silencing of Host Cell CYBB Gene Expression by the Nuclear Effector AnkA of the Intracellular Pathogen Anaplasma phagocytophilum ▿ †

Anaplasma phagocytophilum strains from voles and shrews exhibit specific ankA gene sequences

Anaplasma phagocytophilum strains from voles and shrews exhibit specific ankA gene sequences

Distinct Ecologically Relevant Strains of Anaplasma phagocytophilum

Anaplasma phagocytophilum—a widespread multi-host pathogen with highly adaptive strategies

Distinct Host Species Correlate with Anaplasma phagocytophilum ankA Gene Clusters ▿ †

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Genome-Wide Anaplasma phagocytophilum AnkA-DNA Interactions Are Enriched in Intergenic Regions and Gene Promoters and Correlate with Infection-Induced Differential Gene Expression

High Diversity of ankA Sequences of Anaplasma phagocytophilum among Ixodes ricinus Ticks in Germany

Contribution of Polymorphisms in ankA, gltA, and groESL in Defining Genetic Variants of Anaplasma phagocytophilum ▿ †

Anaplasma phagocytophilum Ankyrin A Protein (AnkA) Enters the Nucleus Using an Importin-β-, RanGTP-Dependent Mechanism

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