NDLI: Chromosome-Encoded AmpC and CTX-M Extended-Spectrum β-Lactamases in Clinical Isolates of Proteus mirabilis from Korea▿

Content Provider	PubMed Central
Author	Song, Wonkeun Kim, Juwon Bae, Il Kwon Jeong, Seok Hoon Seo, Young Hee Shin, Jong Hee Jang, Sook Jin Young, Uh Shin, Jeong Hwan Lee, Mi-kyung Lee, Kyungwon
Copyright Year	2011
Abstract	Among 222 Proteus mirabilis clinical isolates collected from 17 hospitals in Korea in 2008, 28 (12.6%) and 8 (3.6%) isolates exhibited extended-spectrum β-lactamase (ESBL) and AmpC phenotypes, respectively. The most common type of ESBL gene identified by PCR and sequencing experiments was bla CTX-M-14a (n = 12). The bla CTX-M-90 (n = 4), bla CTX-M-15 (n = 3), bla CTX-M-12 (n = 3), bla CTX-M-2 (n = 2), bla CTX-M-14b (n = 1), bla TEM-52 (n = 5), and bla SHV-12 (n = 1) genes were also detected. Eight isolates carried an AmpC β-lactamase gene, such as bla CMY-2 (n = 6) or bla DHA-1 (n = 2). All bla genes encoding CTX-M-1- and CTX-M-9-type enzymes and all bla CMY-2 genes were preceded by ISEcp1-like elements. The bla CTX-M-2 gene found in two isolates was located on a complex class 1 integron. The bla DHA-1 gene was preceded by a transcriptional regulator gene and was followed by phage shock protein genes. The bla CTX-M genes were located on the chromosome in 21 isolates. A plasmid location for the bla CTX-M gene was found in only four isolates: the bla CTX-M-14a gene was located on ∼150-kbp IncA/C plasmids in three isolates and on a ∼50-kbp IncN plasmid in one isolate. The bla TEM-52 gene was located on ∼50-kbp IncN plasmids in all five isolates. The AmpC β-lactamase genes were located on the chromosome in seven of eight isolates; one isolate carried the bla CMY-2 gene on a ∼150-kbp IncA/C plasmid. Our results show that a chromosomal location of CTX-M ESBL and AmpC β-lactamase genes in P. mirabilis is no longer an unusual phenomenon in hospital environments.
Related Links	http://dx.doi.org/10.1128/aac.01835-09
Ending Page	1419
Page Count	6
Starting Page	1414
File Format	PDF
ISSN	00664804
e-ISSN	10986596
Journal	Antimicrobial Agents and Chemotherapy
Issue Number	4
Volume Number	55
Language	English
Publisher	American Society for Microbiology (ASM)
Publisher Date	2011-04-01
Access Restriction	Open
Rights Holder	American Society for Microbiology (ASM)
Subject Keyword	Pharmacology (medical) Pharmacology Infectious Diseases Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Pharmacology Pharmacology (medical)

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