NDLI: Differential Regulation of IL-4Rα Expression by Antigen versus Cytokine Stimulation Characterizes Th2 Progression In Vivo

Content Provider	PubMed Central
Author	Georgia, Perona-wright Mohrs, Katja Mayer, Katrin D. Markus, Mohrs
Copyright Year	2010
Abstract	IL-4 promotes Th2 differentiation and provides immunity to helminth infections but is also associated with allergy and asthma. This suggests that precise adjustment of IL-4 responsiveness is needed to correctly balance immune responses. The IL-4Rα chain is an essential component of the IL-4 receptor and signals via STAT6. In this study, we show that infection with a helminth pathogen elicited broad upregulation of IL-4Rα on bystander CD4+ T cells in the draining lymph node, while simultaneously resulting in the loss of IL-4Rα expression on activated Th2 cells. IL-4Rα upregulation was restricted to the reactive lymph node, occurred within 4 d of infection, and was driven by an IL-4– and STAT6–dependent mechanism. Mice heterozygous for Stat6 exhibited reduced IL-4Rα upregulation and a correspondingly attenuated Th2 response. Indeed, the enhanced IL-4Rα upregulation in BALB/c mice, compared with that in C57BL6 mice, predicted their stronger Th2 response. The selective downregulation of IL-4Rα on highly activated Th cells was triggered by antigenic stimulation, was accompanied by loss of IL-7Rα, and rendered the cells unresponsive to IL-4. Together these data reveal a tightly controlled program of changing IL-4 responsiveness that characterizes the initiation, amplification, and restriction of a Th2 response in vivo.
Related Links	http://dx.doi.org/10.4049/jimmunol.0902408
Ending Page	623
Page Count	9
Starting Page	615
File Format	PDF
ISSN	00221767
e-ISSN	15506606
Journal	Journal of immunology (Baltimore, Md. : 1950)
Issue Number	2
Volume Number	184
Language	English
Publisher Date	2010-01-15
Access Restriction	Open
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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