NDLI: Hypomyelination and increased activity of voltage-gated K+ channels in mice lacking protein tyrosine phosphatase ε

Content Provider	PubMed Central
Author	Peretz, A. Gil-henn, H. Sobko, A. Shinder, V. Attali, B. Elson, A.
Copyright Year	2000
Abstract	Protein tyrosine phosphatase epsilon (PTPε) is strongly expressed in the nervous system; however, little is known about its physiological role. We report that mice lacking PTPε exhibit hypomyelination of sciatic nerve axons at an early post-natal age. This occurs together with increased activity of delayed- rectifier, voltage-gated potassium (Kv) channels and with hyperphosphorylation of Kv1.5 and Kv2.1 Kv channel α-subunits in sciatic nerve tissue and in primary Schwann cells. PTPε markedly reduces Kv1.5 or Kv2.1 current amplitudes in Xenopus oocytes. Kv2.1 associates with a substrate-trapping mutant of PTPε, and PTPε profoundly reduces Src- or Fyn-stimulated Kv2.1 currents and tyrosine phosphorylation in transfected HEK 293 cells. In all, PTPε antagonizes activation of Kv channels by tyrosine kinases in vivo, and affects Schwann cell function during a critical period of Schwann cell growth and myelination.
Related Links	http://dx.doi.org/10.1093/emboj/19.15.4036
Ending Page	4045
Page Count	10
Starting Page	4036
File Format	PDF
ISSN	02614189
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	15
Volume Number	19
Language	English
Publisher	Oxford University Press
Publisher Date	2000-08-01
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Neuroscience(all) Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

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