NDLI: Uncovering Gene Regulatory Networks During Mouse Fetal Germ Cell Development1

Content Provider	PubMed Central
Author	Rolland, Antoine D. Lehmann, Kim P. Johnson, Kamin J. Gaido, Kevin W. Koopman, Peter
Abstract	The commitment of germ cells to either oogenesis or spermatogenesis occurs during fetal gonad development: germ cells enter meiosis or mitotic arrest, depending on whether they reside within an ovary or a testis, respectively. Despite the critical importance of this step for sexual reproduction, gene networks underlying germ cell development have remained only partially understood. Taking advantage of the Wv mouse model, in which gonads lack germ cells, we conducted a microarray study to identify genes expressed in fetal germ cells. In addition to distinguishing genes expressed by germ cells from those expressed by somatic cells within the developing gonads, we were able to highlight specific groups of genes expressed only in female or male germ cells. Our results provide an important resource for deciphering the molecular pathways driving proper germ cell development and sex determination and will improve our understanding of the etiology of human germ cell tumors that arise from dysregulation of germ cell differentiation.
Related Links	http://dx.doi.org/10.1095/biolreprod.110.088443
Ending Page	800
Page Count	11
Starting Page	790
File Format	PDF
ISSN	00063363
e-ISSN	15297268
Journal	Biology of Reproduction
Issue Number	4
Volume Number	84
Language	English
Publisher	Society for the Study of Reproduction, Inc.
Publisher Date	2011-04-01
Access Restriction	Open
Rights Holder	Society for the Study of Reproduction, Inc.
Subject Keyword	Cell Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Reproductive Medicine

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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