NDLI: Homeostasis in the vertebrate lens: mechanisms of solute exchange

Content Provider	PubMed Central
Author	Dahm, Ralf Marle, Jan Van Quinlan, Roy A. Prescott, Alan R. Vrensen, Gijs F. J. M.
Copyright Year	2011
Abstract	The eye lens is avascular, deriving nutrients from the aqueous and vitreous humours. It is, however, unclear which mechanisms mediate the transfer of solutes between these humours and the lens' fibre cells (FCs). In this review, we integrate the published data with the previously unpublished ultrastructural, dye loading and magnetic resonance imaging results. The picture emerging is that solute transfer between the humours and the fibre mass is determined by four processes: (i) paracellular transport of ions, water and small molecules along the intercellular spaces between epithelial and FCs, driven by Na+-leak conductance; (ii) membrane transport of such solutes from the intercellular spaces into the fibre cytoplasm by specific carriers and transporters; (iii) gap-junctional coupling mediating solute flux between superficial and deeper fibres, Na+/K+-ATPase-driven efflux of waste products in the equator, and electrical coupling of fibres; and (iv) transcellular transfer via caveoli and coated vesicles for the uptake of macromolecules and cholesterol. There is evidence that the Na+-driven influx of solutes occurs via paracellular and membrane transport and the Na+/K+-ATPase-driven efflux of waste products via gap junctions. This micro-circulation is likely restricted to the superficial cortex and nearly absent beyond the zone of organelle loss, forming a solute exchange barrier in the lens.
Related Links	http://dx.doi.org/10.1098/rstb.2010.0299
Starting Page	1265
File Format	PDF
ISSN	14712970
e-ISSN	14712970
Journal	Philosophical Transactions of the Royal Society B: Biological Sciences
Issue Number	1568
Volume Number	366
Language	English
Publisher	The Royal Society
Publisher Date	2011-04-27
Access Restriction	Open
Rights Holder	The Royal Society
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology Agricultural and Biological Sciences

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