NDLI: Autotaxin Inhibitors: A Perspective on Initial Medicinal Chemistry Efforts

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Autotaxin Inhibitors: A Perspective on Initial Medicinal Chemistry Efforts

Content Provider	PubMed Central
Author	Parrill, Abby L. Baker, Daniel L.
Abstract	The lysophospholipase D enzyme, autotaxin (ATX), has been linked to numerous human diseases including cancer, neurophatic pain, obesity, and Alzheimer’s disease. Although the ATX protein was initially purified and characterized in 1992, a link to bioactive lipid metabolism was not made until 2002. In the past decade, metal chelators, lysophospholipid product analogs, and more recently small non-lipid inhibitors of the enzyme were successfully identified. The majority of these inhibitors have been characterized using recombinant purified ATX in vitro, with very few examples studied in more complex systems. Translation of ATX inhibitors from the hands of medicinal chemists to clinical use will require substantially expanded characterization of ATX inhibitors in vivo.
Related Links	http://dx.doi.org/10.1517/13543776.2010.533658
Ending Page	1625
Page Count	7
Starting Page	1619
File Format	PDF
ISSN	13543776
e-ISSN	17447674
Journal	Expert opinion on therapeutic patents
Issue Number	12
Volume Number	20
Language	English
Publisher Date	2010-12-01
Access Restriction	Open
Subject Keyword	Pharmacology Drug Discovery Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine Drug Discovery Pharmacology

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