NDLI: Chronic beryllium disease: an updated model interaction between innate and acquired immunity

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Chronic beryllium disease: an updated model interaction between innate and acquired immunity

Content Provider	PubMed Central
Author	Sawyer, Richard T. Maier, Lisa A.
Copyright Year	2010
Abstract	During the last decade, there have been concerted efforts to reduce beryllium (Be) exposure in the workplace and thereby reduce potential cases of this occupational lung disorder. Despite these efforts, it is estimated that there are at least one million Be-exposed individuals in the U.S. who are potentially at risk for developing chronic beryllium disease (CBD). Previously, we reviewed the current CBD literature and proposed that CBD represents a model interaction between innate and acquired immunity (Sawyer et al., Int Immunopharmacol 2:249–261, 2002). We closed this review with a section on “future directions” that identified key gaps in our understanding of the pathogenesis of CBD. In the intervening period, progress has been made to fill in some of these gaps, and the current review will provide an update on that progress. Based on recent findings, we provide a new hypothesis to explain how Be drives sustained chronic inflammation and granuloma formation in CBD leading to progressive compromised lung function in CBD patients. This paradigm has direct implications for our understanding of the development of an immune response to Be, but is also likely applicable to other immune-mediated lung diseases of known and unknown etiology.
Related Links	http://dx.doi.org/10.1007/s10534-010-9376-3
Ending Page	17
Page Count	17
Starting Page	1
File Format	PDF
ISSN	09660844
e-ISSN	15728773
Journal	Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
Issue Number	1
Volume Number	24
Language	English
Publisher Date	2011-02-01
Access Restriction	Open
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Metals and Alloys Biomaterials Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Metals and Alloys Biochemistry, Genetics and Molecular Biology Biomaterials Agricultural and Biological Sciences

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