NDLI: Chemical genetic approaches to probing cell death

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Chemical genetic approaches to probing cell death

Content Provider	PubMed Central
Author	Gangadhar, Nidhi M. Stockwell, Brent R.
Copyright Year	2006
Abstract	Chemical genetics has arisen as a tool for the discovery of pathways and proteins in mammalian systems. This approach, comprising small-molecule screening combined with biochemical and genomic target identification methods, enables one to assess which proteins are involved in regulating a particular phenotype. Applied to cell death, this strategy can reveal novel targets and pathways regulating the demise of mammalian cells. Numerous diseases have been linked to the loss of regulation of cell death. Defining the mechanisms governing cell death in these diseases might lead to the discovery of therapeutic agents and targets and provide a richer understanding of the mortality of living systems. Recent advances include the discovery of novel small molecules regulating cell death pathways — necrostatin and erastin — as well as the elucidation of the mechanism of death induced in cancer cells by the cytotoxic agent Apratoxin A.
Related Links	http://dx.doi.org/10.1016/j.cbpa.2006.11.033
Ending Page	87
Page Count	5
Starting Page	83
File Format	PDF
ISSN	13675931
e-ISSN	18790402
Journal	Current opinion in chemical biology
Issue Number	1
Volume Number	11
Language	English
Publisher Date	2007-02-01
Access Restriction	Open
Subject Keyword	Analytical Chemistry Biochemistry Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Biochemistry

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