NDLI: Tubular silk scaffolds for small diameter vascular grafts

Please wait, while we are loading the content...

Tubular silk scaffolds for small diameter vascular grafts

Content Provider	PubMed Central
Author	Lovett, Michael Eng, George Kluge, Jonathan A. Cannizzaro, Christopher Vunjak-novakovic, Gordana Kaplan, David L.
Copyright Year	2010
Abstract	Vascular surgeries such as coronary artery bypass require small diameter vascular grafts with properties that are not available at this time. Approaches using synthetic biomaterials have not been completely successful in producing non-thrombogenic grafts with inner diameters less than 6 mm, and there is a need for new biomaterials and graft designs. We propose silk fibroin as a microvascular graft material and describe tubular silk scaffolds that demonstrate improved properties over existing vascular graft materials. Silk tubes produced using an aqueous gel spinning technique were first assessed in vitro in terms of thrombogenicity (thrombin and fibrinogen adsorption, platelet adhesion) and vascular cell responses (endothelial and smooth muscle cell attachment and proliferation) in comparison with polytetrafluoroethylene (PTFE), a synthetic material most frequently used for vascular grafts. Silk tubes were then implanted into the abdominal aortas of Sprague-Dawley rats. At time points of 2 weeks and 4 weeks post-implantation, tissue outcomes were assessed through gross observation (acute thrombosis, patency) and histological staining (H&E, Factor VIII, smooth muscle actin). Over the 4-week time period, we observed graft patency and endothelial cell lining of the lumen surfaces. These results demonstrate the feasibility of using silk fibroin as a vascular graft material and some advantages of silk tubes over the currently used synthetic grafts.
Related Links	http://dx.doi.org/10.4161/org.6.4.13407
Ending Page	224
Page Count	8
Starting Page	217
File Format	PDF
ISSN	15476278
e-ISSN	15558592
Journal	Organogenesis
Issue Number	4
Volume Number	6
Language	English
Publisher	Landes Bioscience
Publisher Date	2010-10-01
Access Restriction	Open
Rights Holder	Landes Bioscience
Subject Keyword	Developmental Biology Embryology Transplantation Biomedical Engineering Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Developmental Biology Transplantation Embryology Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Effect of fibroin sponge coating on in vivo performance of knitted silk small diameter vascular grafts

Silk-Based Electrospun Tubular Scaffolds for Tissue-Engineered Vascular Grafts

Development of Small-Diameter Elastin-Silk Fibroin Vascular Grafts

Electrospun biodegradable elastic polyurethane scaffolds with dipyridamole release for small diameter vascular grafts

Acellular Vascular Scaffolds Preloaded With Heparin and Hepatocyte Growth Factor for Small-Diameter Vascular Grafts Might Inhibit Intimal Hyperplasia

Repurposed biological scaffolds: kidney to pancreas

Mesenchymal stem cells support hepatocyte function in engineered liver grafts

Construction of Tissue-Engineered Small-Diameter Vascular Grafts in Fibrin Scaffolds in 30 Days

Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers

Tubular silk scaffolds for small diameter vascular grafts

Similar Documents

Effect of fibroin sponge coating on in vivo performance of knitted silk small diameter vascular grafts

Silk-Based Electrospun Tubular Scaffolds for Tissue-Engineered Vascular Grafts

Development of Small-Diameter Elastin-Silk Fibroin Vascular Grafts

Electrospun biodegradable elastic polyurethane scaffolds with dipyridamole release for small diameter vascular grafts

Acellular Vascular Scaffolds Preloaded With Heparin and Hepatocyte Growth Factor for Small-Diameter Vascular Grafts Might Inhibit Intimal Hyperplasia

Repurposed biological scaffolds: kidney to pancreas

Mesenchymal stem cells support hepatocyte function in engineered liver grafts

Construction of Tissue-Engineered Small-Diameter Vascular Grafts in Fibrin Scaffolds in 30 Days

Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers

Tubular silk scaffolds for small diameter vascular grafts