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| Content Provider | PubMed Central |
|---|---|
| Author | Yun, Hwan-jung Jo, Deog-yeon |
| Abstract | This study investigated the production of stromal cell-derived factor-1 (SDF-1) and the expression of CXCR4 in human bone marrow endothelial cells (BMECs). Human BMEC cell line BMEC-1 cells expressed SDF-1 mRNA, and conditioned medium induced chemoattraction of CD34+ cells. Migration was not inhibited by pretreating the input cells with pertussis toxin, indicating that the chemoattractive activity was not dependent on SDF-1. Three-day culture of BMEC-1 and primary human BMEC cells produced 1,710+/-204 and 1,050+/-153 pg/mL SDF-1alpha, respectively, which was much less than primary human BM stromal cells (29,536+/-532 pg/ mL). By immuno-histochemistry, CXCR4 was detected in the endothelial cells lining sinusoids, arterioles, and venules in the bone marrow. However, cultured BMECs and BMEC-1 cells did not express CXCR4 on their surfaces. These results indicate that BMECs produce and release small amounts of SDF-1 and express CXCR4 in vivo only. |
| Related Links | http://dx.doi.org/10.3346/jkms.2003.18.5.679 |
| Starting Page | 679 |
| File Format | |
| ISSN | 10118934 |
| e-ISSN | 15986357 |
| Journal | Journal of Korean Medical Science |
| Issue Number | 5 |
| Volume Number | 18 |
| Language | English |
| Publisher | Korean Academy of Medical Sciences |
| Publisher Date | 2003-01-01 |
| Access Restriction | Open |
| Rights Holder | Korean Academy of Medical Sciences |
| Subject Keyword | Medicine(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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