NDLI: Chronic wasting disease prions are not transmissible to transgenic mice overexpressing human prion protein

Content Provider	PubMed Central
Author	Sandberg, Malin K. Huda, Al-doujaily Sigurdson, Christina J. Glatzel, Markus O'malley, Catherine Powell, Caroline Asante, Emmanuel A. Linehan, Jacqueline M. Brandner, Sebastian Wadsworth, Jonathan D. F. Collinge, John
Copyright Year	2010
Abstract	Chronic wasting disease (CWD) is a prion disease that affects free-ranging and captive cervids, including mule deer, white-tailed deer, Rocky Mountain elk and moose. CWD-infected cervids have been reported in 14 USA states, two Canadian provinces and in South Korea. The possibility of a zoonotic transmission of CWD prions via diet is of particular concern in North America where hunting of cervids is a popular sport. To investigate the potential public health risks posed by CWD prions, we have investigated whether intracerebral inoculation of brain and spinal cord from CWD-infected mule deer transmits prion infection to transgenic mice overexpressing human prion protein with methionine or valine at polymorphic residue 129. These transgenic mice have been utilized in extensive transmission studies of human and animal prion disease and are susceptible to BSE and vCJD prions, allowing comparison with CWD. Here, we show that these mice proved entirely resistant to infection with mule deer CWD prions arguing that the transmission barrier associated with this prion strain/host combination is greater than that observed with classical BSE prions. However, it is possible that CWD may be caused by multiple prion strains. Further studies will be required to evaluate the transmission properties of distinct cervid prion strains as they are characterized.
Related Links	http://dx.doi.org/10.1099/vir.0.024380-0
Ending Page	2657
Page Count	7
Starting Page	2651
File Format	PDF
ISSN	00221317
e-ISSN	14652099
Journal	The Journal of General Virology
Issue Number	Pt 10
Volume Number	91
Language	English
Publisher	Society for General Microbiology
Publisher Date	2010-10-01
Access Restriction	Open
Rights Holder	Society for General Microbiology
Subject Keyword	Virology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Virology

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