NDLI: Current status and future directions of gene expression profiling in Parkinson’s disease

Content Provider	PubMed Central
Author	Greene, James G.
Copyright Year	2010
Abstract	Parkinson’s disease (PD) is a common age-associated neurodegenerative disorder. Motor symptoms are the cardinal component of PD, but non-motor symptoms, such as dementia, depression, and autonomic dysfunction are being increasingly recognized. Motor symptoms are primarily caused by selective degeneration of substantia nigra dopamine (SNDA) neurons in the midbrain; non-motor symptoms may be referable to well-described pathology at multiple levels of the neuraxis. Development of symptomatic and disease-modifying therapies is dependent on an accurate and comprehensive understanding of the pathogenesis and pathophysiology of PD. Gene expression profiling has been recently employed to assess function on a broad level in the hopes of gaining greater knowledge concerning how individual mechanisms of disease fit together as a whole and to generate novel hypotheses concerning PD pathogenesis, diagnosis, and progression. So far, the majority of studies have been performed on postmortem brain samples from PD patients, but more recently, studies have targeted enriched populations of dopamine neurons and have begun to explore extra-nigral neurons and even peripheral tissues. This review will provide a brief synopsis of gene expression profiling in parkinsonism and its pitfalls to date and propose several potential future directions and uses for the technique. It will focus on the use of microarray experiments to stimulate hypotheses concerning mechanisms of neurodegeneration in PD, since the majority of studies thus far have addressed that complicated issue.
Related Links	http://dx.doi.org/10.1016/j.nbd.2010.10.022
Ending Page	82
Page Count	7
Starting Page	76
File Format	PDF
ISSN	09699961
e-ISSN	1095953X
Journal	Neurobiology of disease
Issue Number	1
Volume Number	45
Language	English
Publisher Date	2012-01-01
Access Restriction	Open
Subject Keyword	Neurology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neurology

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