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| Content Provider | PubMed Central |
|---|---|
| Author | Yu, Fu-shin Cornicelli, Matthew D. Kovach, Melissa A. Newstead, Michael W. Zeng, Xianying Kumar, Ashok Gao, Nan Yoon, Sang Gi Gallo, Richard L. Standiford, Theodore J. |
| Abstract | Toll like receptors are required for generation of protective lung mucosal immune responses against microbial pathogens. In this study, we evaluated the effect of the TLR5 ligand flagellin on stimulation of antibacterial mucosal immunity in a lethal murine Pseudomonas aeruginosa (PA) pneumonia model. The intranasal pretreatment of mice with purified PA flagellin induced strong protection against intratracheal PA-induced lethality, which was attributable to markedly improved bacterial clearance, reduced dissemination, and decreased alveolar permeability. The protective effects of flagellin on survival required TLR5, and was observed even in the absence of neutrophils. Flagellin induced strong induction of innate genes, most notably the antimicrobial peptide cathelicidin related antimicrobial peptide (CRAMP). Finally, flagellin-induced protection was partially abrogated in CRAMP deficient mice. Our findings illustrate the profound stimulatory effect of flagellin on lung mucosal innate immunity, a response that might be exploited therapeutically to prevent the development of Gram-negative bacterial infection of the respiratory tract. |
| Related Links | http://dx.doi.org/10.4049/jimmunol.1000509 |
| Starting Page | 1142 |
| File Format | |
| ISSN | 15506606 |
| e-ISSN | 15506606 |
| Journal | Journal of immunology (Baltimore, Md. : 1950) |
| Issue Number | 2 |
| Volume Number | 185 |
| Language | English |
| Publisher Date | 2010-07-15 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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