NDLI: Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes

Content Provider	PubMed Central
Author	Monsalvo, Ana Clara Batalle, Juan P. Lopez, M. Florencia Krause, Jens C. Klemenc, Jennifer Zea, Johanna Maskin, Bernardo Bugna, Jimena Rubinstein, Carlos Aguilar, Leandro Dalurzo, Liliana Libster, Romina Savy, Vilma Baumeister, Elsa Aguilar, Liliana Cabral, Graciela Font, Julia Solari, Liliana Weller, Kevin P. Johnson, Joyce Echavarria, Marcela Edwards, Kathryn M. Chappell, James D. Crowe, James E. Williams, John V. Melendi, Guillermina A. Polack, Fernando P.
Abstract	Pandemic influenza viruses often cause severe disease in middle-aged adults without preexistent co-morbidities. The mechanism of illness associated with severe disease in this age group is not well understood1–10. Here, we demonstrate preexisting serum antibody that cross-reacts with, but does not protect against 2009 H1N1 influenza virus in middle-aged adults. Non-protective antibody is associated with immune complex(IC)-mediated disease after infection. High titers of serum antibody of low avidity for H1-2009 antigen, and low avidity pulmonary ICs against the same protein were detected in severely ill patients. Moreover, C4d deposition - a sensitive marker of complement activation mediated by ICs- was present in lung sections of fatal cases. Archived lung sections from adults with confirmed fatal influenza 1957 H2N2 infection revealed a similar mechanism of illness. These observations provide a novel biological mechanism for the unusual age distribution of severe cases during influenza pandemics.
Related Links	http://dx.doi.org/10.1038/nm.2262
Ending Page	199
Page Count	5
Starting Page	195
File Format	PDF
ISSN	10788956
e-ISSN	1546170X
Journal	Nature medicine
Issue Number	2
Volume Number	17
Language	English
Publisher Date	2011-02-01
Access Restriction	Open
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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