NDLI: Regulation of nleA in Shiga Toxin-Producing Escherichia coli O84:H4 Strain 4795/97▿ †

Content Provider	PubMed Central
Author	Maike, Schwidder Hensel, Michael Schmidt, Herbert
Copyright Year	2011
Abstract	Many Shiga toxin-producing Escherichia coli (STEC) strains express a type III secretion system (TTSS) encoded by the locus of enterocyte effacement (LEE). Using the TTSS, STEC is able to inject effector proteins directly into eukaryotic host cells, where they cause characteristic attaching and effacing (A/E) lesions. In addition to the LEE-encoded effectors, a number of non-LEE-encoded effectors, located on phage-associated elements, have been described. One of them, the non-LEE-encoded effector A (NleA), is widely distributed among pathogenic E. coli. In this study, we investigated the influence of environmental conditions on the expression of the phage-encoded effector nleA gene (designated nleA 4795) present in STEC O84:H4 strain 4795/97. We demonstrated that a particular NaCl concentration and starvation stress increase the activity of the nleA 4795 promoter. Moreover, several regulators that control nleA 4795 expression were identified. The involvement of the LEE regulators Ler, GrlA, and GrlR show that nleA 4795 is integrated in the LEE regulation circuit. Furthermore, the binding of Ler to sequences upstream of nleA 4795 underlined these findings.
Related Links	http://dx.doi.org/10.1128/jb.00582-10
Ending Page	841
Page Count	10
Starting Page	832
File Format	PDF
ISSN	00219193
e-ISSN	10985530
Journal	Journal of Bacteriology
Issue Number	4
Volume Number	193
Language	English
Publisher	American Society for Microbiology (ASM)
Publisher Date	2011-02-15
Access Restriction	Open
Rights Holder	American Society for Microbiology (ASM)
Subject Keyword	Molecular Biology Microbiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Microbiology

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