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| Content Provider | PubMed Central |
|---|---|
| Author | Kumar, Sanjeev Mahdi, Haider Bryant, Christopher Shah, Jay P. Garg, Gunjal Adnan, Munkarah |
| Abstract | Paclitaxel is a front-line agent for ovarian cancer chemotherapy, along with the platinum agents. Derived from the Pacific yew tree, Taxus brevifolia, paclitaxel has covered significant ground from the initial discovery of its antineoplastic properties to clinical applications in many forms of human cancers, including ovarian cancer. Although much has been published about the unique mechanism of action of this agent, several issues remain to be resolved. Finding the appropriate dosage schedule for paclitaxel in chemo-naïve and recurrent ovarian cancer, defining the role of paclitaxel in maintenance chemotherapy, and elucidating the mechanisms of taxane resistance are areas of intense research. Newer forms of taxanes are being manufactured to avoid troublesome adverse effects and to improve clinical efficacy. These issues are reviewed in detail in this paper with an emphasis on clinically relevant evidence-based information. |
| Related Links | http://dx.doi.org/10.2147/ijwh.s7012 |
| Ending Page | 427 |
| Starting Page | 411 |
| File Format | |
| ISSN | 11791411 |
| e-ISSN | 11791411 |
| Journal | International Journal of Women's Health |
| Volume Number | 2 |
| Language | English |
| Publisher | Dove Medical Press |
| Publisher Date | 2010-11-01 |
| Access Restriction | Open |
| Rights Holder | Dove Medical Press |
| Subject Keyword | Obstetrics and Gynaecology Maternity and Midwifery Oncology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Maternity and Midwifery Obstetrics and Gynecology Oncology |
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