NDLI: Post-Traumatic Seizures Exacerbate Histopathological Damage after Fluid-Percussion Brain Injury

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Post-Traumatic Seizures Exacerbate Histopathological Damage after Fluid-Percussion Brain Injury

Content Provider	PubMed Central
Author	Bao, Ying-hui Bramlett, Helen M. Atkins, Coleen M. Truettner, Jessie S. George, Lotocki Alonso, Ofelia F. Dietrich, W. Dalton
Abstract	The purpose of this study was to investigate the effects of an induced period of post-traumatic epilepsy (PTE) on the histopathological damage caused by traumatic brain injury (TBI). Male Sprague Dawley rats were given a moderate parasagittal fluid-percussion brain injury (1.9–2.1 atm) or sham surgery. At 2 weeks after surgery, seizures were induced by administration of a GABAA receptor antagonist, pentylenetetrazole (PTZ, 30 mg/kg). Seizures were then assessed over a 1-h period using the Racine clinical rating scale. To evaluate whether TBI-induced pathology was exacerbated by the seizures, contusion volume and cortical and hippocampal CA3 neuronal cell loss were measured 3 days after seizures. Nearly all TBI rats showed clinical signs of PTE following the decrease in inhibitory activity. In contrast, clinically evident seizures were not observed in TBI rats given saline or sham-operated rats given PTZ. Contusions in TBI-PTZ-treated rats were significantly increased compared to the TBI-saline-treated group (p < 0.001). In addition, the TBI-PTZ rats showed less NeuN-immunoreactive cells within the ipsilateral parietal cerebral cortex (p < 0.05) and there was a trend for decreased hippocampal CA3 neurons in TBI-PTZ rats compared with TBI-saline or sham-operated rats. These results demonstrate that an induced period of post-traumatic seizures significantly exacerbates the structural damage caused by TBI. These findings emphasize the need to control seizures after TBI to limit even further damage to the injured brain.
Related Links	http://dx.doi.org/10.1089/neu.2010.1383
Ending Page	42
Page Count	8
Starting Page	35
File Format	PDF
ISSN	08977151
e-ISSN	15579042
Journal	Journal of Neurotrauma
Issue Number	1
Volume Number	28
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2011-01-01
Access Restriction	Open
Rights Holder	Mary Ann Liebert, Inc.
Subject Keyword	Clinical Neurology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical)

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