NDLI: Identifying and validating biomarkers for Alzheimer's disease

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Identifying and validating biomarkers for Alzheimer's disease

Content Provider	PubMed Central
Author	Christian, Humpel
Copyright Year	2010
Abstract	The identification and validation of biomarkers for diagnosing Alzheimer's disease (AD) and other forms of dementia are increasingly important. To date, ELISA measurement of β-amyloid(1–42), total tau and phospho-tau-181 in cerebrospinal fluid (CSF) is the most advanced and accepted method to diagnose probable AD with high specificity and sensitivity. However, it is a great challenge to search for novel biomarkers in CSF and blood by using modern potent methods, such as microarrays and mass spectrometry, and to optimize the handling of samples (e.g. collection, transport, processing, and storage), as well as the interpretation using bioinformatics. It seems likely that only a combined analysis of several biomarkers will define a patient-specific signature to diagnose AD in the future.
Related Links	http://dx.doi.org/10.1016/j.tibtech.2010.09.007
Ending Page	32
Page Count	7
Starting Page	26
File Format	PDF
ISSN	01677799
e-ISSN	18793096
Journal	Trends in Biotechnology
Issue Number	1
Volume Number	29
Language	English
Publisher	Elsevier Science Publishers
Publisher Date	2011-01-01
Access Restriction	Open
Rights Holder	Elsevier Science Publishers
Subject Keyword	Biotechnology Bioengineering Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Bioengineering Biotechnology

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