NDLI: DAnCER: Disease-Annotated Chromatin Epigenetics Resource

Content Provider	PubMed Central
Author	Turinsky, Andrei L. Turner, Brian Borja, Rosanne C. Gleeson, James A. Heath, Michael Pu, Shuye Switzer, Thomas Dong, Dong Gong, Yunchen On, Tuan Xiong, Xuejian Emili, Andrew Greenblatt, Jack Parkinson, John Zhang, Zhaolei Wodak, Shoshana J.
Copyright Year	2010
Abstract	Chromatin modification (CM) is a set of epigenetic processes that govern many aspects of DNA replication, transcription and repair. CM is carried out by groups of physically interacting proteins, and their disruption has been linked to a number of complex human diseases. CM remains largely unexplored, however, especially in higher eukaryotes such as human. Here we present the DAnCER resource, which integrates information on genes with CM function from five model organisms, including human. Currently integrated are gene functional annotations, Pfam domain architecture, protein interaction networks and associated human diseases. Additional supporting evidence includes orthology relationships across organisms, membership in protein complexes, and information on protein 3D structure. These data are available for 962 experimentally confirmed and manually curated CM genes and for over 5000 genes with predicted CM function on the basis of orthology and domain composition. DAnCER allows visual explorations of the integrated data and flexible query capabilities using a variety of data filters. In particular, disease information and functional annotations are mapped onto the protein interaction networks, enabling the user to formulate new hypotheses on the function and disease associations of a given gene based on those of its interaction partners. DAnCER is freely available at http://wodaklab.org/dancer/.
Related Links	http://dx.doi.org/10.1093/nar/gkq857
Starting Page	889
File Format	PDF
ISSN	03051048
e-ISSN	13624962
Journal	Nucleic Acids Research
Issue Number	Database issue
Volume Number	39
Language	English
Publisher	Oxford University Press
Publisher Date	2011-01-01
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Genetics Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics

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