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| Content Provider | PubMed Central |
|---|---|
| Author | Kumar, Shaji Angela, Dispenzieri Katzmann, Jerry A. Larson, Dirk R. Colby, Colin L. Lacy, Martha Q. Hayman, Suzanne R. Buadi, Francis K. Leung, Nelson Zeldenrust, Steve R. Marina, Ramirez-alvarado Clark, Raynell J. Kyle, Robert A. Rajkumar, S. Vincent Gertz, Morie A. |
| Abstract | Immunoglobulin free light chains (FLCs) are the precursors of amyloid fibrils in primary amyloidosis (AL). We studied the relationship between FLC levels and clinical features in 730 patients with newly diagnosed AL. The plasma cell clone was λ in 72% patients, and κ in 28% patients. κ-AL had more GI tract and liver involvement, where as renal involvement was more with λ-AL. While the overall survival (OS) was similar for κ and λ-AL, the median OS for those without an identifiable serum heavy chain was significantly shorter (12.6 vs 29.9 months; P = .02). The OS was shorter among those with a higher dFLC (involved FLC−uninvolved FLC; κ > 29.4 mg/dL or λ > 18.2 mg/dL using median for cutoff); 10.9 vs 37.1 months; P < .001. In multivariate analysis, dFLC was independent of other prognostic factors. The type of light chain impacts the spectrum of organ involvement and the FLC burden correlates with survival in AL. |
| Related Links | http://dx.doi.org/10.1182/blood-2010-06-290668 |
| Ending Page | 5129 |
| Page Count | 4 |
| Starting Page | 5126 |
| File Format | |
| ISSN | 00064971 |
| e-ISSN | 15280020 |
| Journal | Blood |
| Issue Number | 24 |
| Volume Number | 116 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2010-12-09 |
| Access Restriction | Open |
| Rights Holder | American Society of Hematology |
| Subject Keyword | Immunology Cell Biology Biochemistry Hematology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Hematology Biochemistry Immunology |
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