NDLI: Tomosyn Expression Pattern in the Mouse Hippocampus Suggests Both Presynaptic and Postsynaptic Functions

Content Provider	PubMed Central
Author	Barak, Boaz Williams, Antionette Noa, Bielopolski Gottfried, Irit Okun, Eitan Brown, Meghan A. Matti, Ulf Rettig, Jens Stuenkel, Edward L. Ashery, Uri
Copyright Year	2010
Abstract	The protein tomosyn decreases synaptic transmission and release probability of vesicles, and is essential for modulating synaptic transmission in neurons. In this study, we provide a detailed description of the expression and localization patterns of tomosyn1 and tomosyn2 in the subareas of the mouse hippocampus. Using confocal and two-photon high-resolution microscopy we demonstrate that tomosyn colocalizes with several pre- and postsynaptic markers and is found mainly in glutamatergic synapses. Specifically, we show that tomosyn1 is differentially distributed in the mouse hippocampus and concentrated mainly in the hilus and mossy fibers. Surprisingly, we found that tomosyn2 is expressed in the subiculum, CA1 and CA2 pyramidal cell bodies, dendrites and spines, and colocalizes with PSD95, suggesting a postsynaptic role. These results suggest that in addition to the well-characterized presynaptic function of tomosyn in neurotransmitter release, tomosyn2 might have a postsynaptic function, and place tomosyn as a more general regulator of synaptic transmission and plasticity.
Related Links	http://dx.doi.org/10.3389/fnana.2010.00149
Starting Page	149
File Format	PDF
ISSN	16625129
e-ISSN	16625129
Journal	Frontiers in Neuroanatomy
Volume Number	4
Language	English
Publisher	Frontiers Research Foundation
Publisher Date	2010-01-01
Access Restriction	Open
Rights Holder	Frontiers Research Foundation
Subject Keyword	Anatomy Cellular and Molecular Neuroscience Neuroscience (miscellaneous) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Anatomy Cellular and Molecular Neuroscience

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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