NDLI: THE TWISTS AND TURNS OF SPHINGOLIPID PATHWAY IN GLUCOSE REGULATION

Please wait, while we are loading the content...

THE TWISTS AND TURNS OF SPHINGOLIPID PATHWAY IN GLUCOSE REGULATION

Content Provider	PubMed Central
Author	Deevska, Gergana M. Nikolova-karakashian, Mariana N.
Copyright Year	2010
Abstract	Palmitic acid is a saturated fat found in foods that lead to obesity, cardiovascular disease, and Type II diabetes. It is linked to the development of resistance to insulin stimulation in muscle, liver and other organs involved in glucose metabolism, which, in turn, underlines the onset of Type II diabetes. The cellular and molecular mechanisms of this insulin resistance are complex and not completely understood. This article is focused on the role of palmitic acid as a precursor in the synthesis of sphingolipids, a class of lipid molecules that participate in cellular stress response. Recent evidence had indicated that increased dietary supply of palmitate can stimulate the rate of sphingolipid synthesis in “lean” tissues and generate excessive amounts of sphingolipid metabolites that have a negative effect on the insulin signaling cascade. Many experimental results point to the existence of a causative link between sphingolipid synthesis, insulin response, and hyperglycemia. It is not yet clear, however whether ceramides or glycosphingolipids are involved as both have been implicated to be inhibitors of the insulin signaling cascade. Evidence for a coordinated regulation of sphingolipid and tri/diacylglycerol metabolism complicates further the delineation of a single mechanism of sphingolipid effect on glucose homeostasis.
Related Links	http://dx.doi.org/10.1016/j.biochi.2010.05.016
Ending Page	38
Page Count	7
Starting Page	32
File Format	PDF
ISSN	03009084
e-ISSN	16386183
Journal	Biochimie
Issue Number	1
Volume Number	93
Language	English
Publisher Date	2011-01-01
Access Restriction	Open
Subject Keyword	Biochemistry Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Twists and turns in ubiquitin-like protein conjugation cascades†

The Par-4-GRP78 TRAIL, more Twists and Turns

Twists and turns of DNA methylation

The Twists and Turns of Enzyme Function▿

Rickets: Twists and turns in the Gordian knot

Twists and Turns: My Career Path and Concerns About the Future

Sphingosine Kinase: Role in Regulation of Bioactive Sphingolipid Mediators in Inflammation

Twists and turns on the way to progress in metastatic castrate-resistant prostate cancer

ARAP2 promotes GLUT1-mediated basal glucose uptake through regulation of sphingolipid metabolism

THE TWISTS AND TURNS OF SPHINGOLIPID PATHWAY IN GLUCOSE REGULATION

Similar Documents

Twists and turns in ubiquitin-like protein conjugation cascades†

The Par-4-GRP78 TRAIL, more Twists and Turns

Twists and turns of DNA methylation

The Twists and Turns of Enzyme Function▿

Rickets: Twists and turns in the Gordian knot

Twists and Turns: My Career Path and Concerns About the Future

Sphingosine Kinase: Role in Regulation of Bioactive Sphingolipid Mediators in Inflammation

Twists and turns on the way to progress in metastatic castrate-resistant prostate cancer

ARAP2 promotes GLUT1-mediated basal glucose uptake through regulation of sphingolipid metabolism

THE TWISTS AND TURNS OF SPHINGOLIPID PATHWAY IN GLUCOSE REGULATION