NDLI: Drosophila provides rapid modeling of renal development, function, and disease

Content Provider	PubMed Central
Author	Dow, Julian A. T. Romero, Michael F.
Abstract	The evolution of specialized excretory cells is a cornerstone of the metazoan radiation, and the basic tasks performed by Drosophila and human renal systems are similar. The development of the Drosophila renal (Malpighian) tubule is a classic example of branched tubular morphogenesis, allowing study of mesenchymal-to-epithelial transitions, stem cell-mediated regeneration, and the evolution of a glomerular kidney. Tubule function employs conserved transport proteins, such as the Na+, K+-ATPase and V-ATPase, aquaporins, inward rectifier K+ channels, and organic solute transporters, regulated by cAMP, cGMP, nitric oxide, and calcium. In addition to generation and selective reabsorption of primary urine, the tubule plays roles in metabolism and excretion of xenobiotics, and in innate immunity. The gene expression resource FlyAtlas.org shows that the tubule is an ideal tissue for the modeling of renal diseases, such as nephrolithiasis and Bartter syndrome, or for inborn errors of metabolism. Studies are assisted by uniquely powerful genetic and transgenic resources, the widespread availability of mutant stocks, and low-cost, rapid deployment of new transgenics to allow manipulation of renal function in an organotypic context.
Related Links	http://dx.doi.org/10.1152/ajprenal.00521.2010
Starting Page	1237
File Format	PDF
ISSN	03636127
e-ISSN	15221466
Journal	American Journal of Physiology - Renal Physiology
Issue Number	6
Volume Number	299
Language	English
Publisher	American Physiological Society
Publisher Date	2010-12-01
Access Restriction	Open
Rights Holder	American Physiological Society
Subject Keyword	Physiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Drosophila provides rapid modeling of renal development, function, and disease

myb provides an essential function during Drosophila development

Mislocalization of mitochondria and compromised renal function and oxidative stress resistance in Drosophila SesB mutants

The Drosophila NKCC Ncc69 is required for normal renal tubule function

Impaired renal function and development in Belgrade rats

Recovery of renal function after glucocorticoid therapy for IgG4-related kidney disease with renal dysfunction

End-stage renal disease preceded by rapid declines in kidney function: a case series

Function-informed transcriptome analysis of Drosophila renal tubule

Development of a definition for Rapid Progression (RP) of renal function in HIV-positive persons: the D:A:D study

Drosophila provides rapid modeling of renal development, function, and disease

Similar Documents

Drosophila provides rapid modeling of renal development, function, and disease

myb provides an essential function during Drosophila development

Mislocalization of mitochondria and compromised renal function and oxidative stress resistance in Drosophila SesB mutants

The Drosophila NKCC Ncc69 is required for normal renal tubule function

Impaired renal function and development in Belgrade rats

Recovery of renal function after glucocorticoid therapy for IgG4-related kidney disease with renal dysfunction

End-stage renal disease preceded by rapid declines in kidney function: a case series

Function-informed transcriptome analysis of Drosophila renal tubule

Development of a definition for Rapid Progression (RP) of renal function in HIV-positive persons: the D:A:D study

Drosophila provides rapid modeling of renal development, function, and disease