NDLI: Functional response in ventral temporal cortex differentiates mild cognitive impairment from normal aging

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Groupwise Registration Based on Hierarchical Image Clustering and Atlas Synthesis

Functional response in ventral temporal cortex differentiates mild cognitive impairment from normal aging

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Functional response in ventral temporal cortex differentiates mild cognitive impairment from normal aging

Content Provider	PubMed Central
Author	Gold, Brian T. Jiang, Yang Jicha, Greg A. Smith, Charles D.
Abstract	The present study sought to identify altered brain activation patterns in amnestic mild cognitive impairment (MCI) that could precede frank task impairment and neocortical atrophy. A high accuracy lexical decision (LD) task was therefore employed. Both MCI and normal senior (NS) groups completed the LD task while functional magnetic resonance imaging (fMRI) was performed. Accuracy on the LD task was high (≥ 89% correct for both groups), and both groups activated a network of occipitotemporal regions and inferior frontal cortex. However, compared to the NS group, the MCI group showed reduced fMRI activation in these regions and increased activation in bilateral portions of anterior cingluate cortex. Results from a voxel-based morphometry analysis indicate that altered activations in the MCI group were not within regions of atrophy. Receiver operating characteristic curves demonstrate that reduced fMRI response in the left and right mid-fusiform gyri accurately discriminate MCI from NS. When activation magnitude in both fusiform gyri were included in a single logistic regression model, group classification accuracy was very high (area under the curve = 0.93). These results show that a disrupted functional response in the ventral temporal lobe accurately distinguishes individuals with MCI from normal seniors, a finding which may have implications for identifying seniors at risk for cognitive decline.
Related Links	http://dx.doi.org/10.1002/hbm.20932
Page Count	1
Starting Page	1249
File Format	PDF
ISSN	10659471
e-ISSN	10970193
Journal	Human brain mapping
Issue Number	8
Volume Number	31
Language	English
Publisher Date	2009-01-01
Access Restriction	Open
Subject Keyword	Anatomy Radiological and Ultrasound Technology Radiology Nuclear Medicine and imaging Neurology Clinical Neurology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Anatomy Neurology Radiology, Nuclear Medicine and Imaging Neurology (clinical) Radiological and Ultrasound Technology

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