NDLI: Multiple loci contribute to genome-wide recombination levels in male mice

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Multiple loci contribute to genome-wide recombination levels in male mice

Content Provider	PubMed Central
Author	Murdoch, Brenda Owen, Nichole Shirley, Sofia Crumb, Sara Broman, Karl W. Hassold, Terry
Abstract	Recent linkage-based studies in humans suggest the presence of loci that affect either genome-wide recombination rates, utilization of recombination hotspots, or both. We have been interested in utilizing cytological methodology to directly assess recombination in mammalian meiocytes and to identify recombination-associated loci. In the present report we summarize studies in which we combined a cytological assay of recombination in mouse pachytene spermatocytes with QTL analyses to identify loci that contribute to genome-wide levels of recombination in male meiosis. Specifically, we analyzed MLH1 foci, a marker of crossovers, in 194 F2 male mice derived from a subspecific cross between CAST/EiJ and C57BL/6J parental strains. We then used these data to uncover loci associated with individual variation in mean MLH1 values. We identified seven recombination-associated loci across the genome (on chromosomes 2, 3, 4, 14, 15, 17, and X), indicating that there are multiple recombination “setting” loci in mammalian male meiosis.
Related Links	http://dx.doi.org/10.1007/s00335-010-9303-5
Ending Page	555
Page Count	6
Starting Page	550
File Format	PDF
ISSN	09388990
e-ISSN	14321777
Journal	Mammalian Genome
Issue Number	11-12
Volume Number	21
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-12-01
Access Restriction	Open
Rights Holder	Springer-Verlag
Subject Keyword	Genetics Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics

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