NDLI: An essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and the development of natural killer T cells

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An essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and the development of natural killer T cells

Content Provider	PubMed Central
Author	D’cruz, Louise M. Knell, Jamie Fujimoto, Jessica K. Goldrath, Ananda W.
Abstract	E proteins are basic helix-loop-helix transcription factors that regulate many key aspects of lymphocyte development. Thymocytes express multiple E proteins that are thought to provide cooperative and compensatory functions crucial for T cell differentiation. Contrary to that, we report here that the E protein HEB was uniquely required at the CD4+CD8+ double-positive (DP) stage of T cell development. Thymocytes lacking HEB showed impaired survival, failed to make rearrangements of variable-α (Vα) segments to distal joining-α (Jα) segments in the gene encoding the T cell antigen receptor α-chain (Tcra) and had a profound, intrinsic block in the development of invariant natural killer T cells (iNKT cells) at their earliest progenitor stage. Thus, our results show that HEB is a specific and essential factor in T cell development and in the generation of the iNKT cell lineage, defining a unique role for HEB in the regulation of lymphocyte maturation.
Related Links	http://dx.doi.org/10.1038/ni.1845
Ending Page	249
Page Count	10
Starting Page	240
File Format	PDF
ISSN	15292908
e-ISSN	15292916
Journal	Nature immunology
Issue Number	3
Volume Number	11
Language	English
Publisher Date	2010-03-01
Access Restriction	Open
Subject Keyword	Immunology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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