NDLI: Maternal Alcohol Consumption, Alcohol Metabolism Genes, and the Risk of Oral Clefts: A Population-based Case-Control Study in Norway, 1996

Content Provider	PubMed Central
Author	Boyles, Abee L. Deroo, Lisa A. Lie, Rolv T. Taylor, Jack A. Jugessur, Astanand Murray, Jeffrey C. Wilcox, Allen J.
Copyright Year	2010
Abstract	Heavy maternal alcohol consumption during early pregnancy increases the risk of oral clefts, but little is known about how genetic variation in alcohol metabolism affects this association. Variants in the alcohol dehydrogenase 1C (ADH1C) gene may modify the association between alcohol and clefts. In a population-based case-control study carried out in Norway (1996–2001), the authors examined the association between maternal alcohol consumption and risk of oral clefts according to mother and infant ADH1C haplotypes encoding fast or slow alcohol-metabolizing phenotypes. Subjects were 483 infants with oral cleft malformations and 503 control infants and their mothers, randomly selected from all other livebirths taking place during the same period. Mothers who consumed 5 or more alcoholic drinks per sitting during the first trimester of pregnancy had an elevated risk of oral cleft in their offspring (odds ratio (OR) = 2.6, 95% confidence interval (CI): 1.4, 4.7). This increased risk was evident only in mothers or children who carried the ADH1C haplotype associated with reduced alcohol metabolism (OR= 3.0, 95% CI: 1.4, 6.8). There was no evidence of alcohol-related risk when both mother and infant carried only the rapid-metabolism ADH1C variant (OR = 0.9, 95% CI: 0.2, 4.1). The teratogenic effect of alcohol may depend on the genetic capacity of the mother and fetus to metabolize alcohol.
Related Links	http://dx.doi.org/10.1093/aje/kwq226
Ending Page	931
Page Count	8
Starting Page	924
File Format	PDF
ISSN	00029262
e-ISSN	14766256
Journal	American Journal of Epidemiology
Issue Number	8
Volume Number	172
Language	English
Publisher	Oxford University Press
Publisher Date	2010-10-15
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Epidemiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Epidemiology

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