NDLI: Cortical cholingeric abnormalities contribute to the amnesic state induced by pyrithiamine-induced thiamine deficiency in the rat

Content Provider	PubMed Central
Author	Anzalone, Steven Vetreno, Ryan P. Ramos, Raddy L. Savage, Lisa M.
Abstract	Although the key neuropathology associated with diencephalic amnesia are lesions to the thalamus and/or mammillary bodies, functional deactivation of the hippocampus and associated cortical regions also appear to contribute to the memory dysfunction. For example, there is loss of forebrain cholinergic neurons and alterations in stimulated acetylcholine (ACh) levels in hippocampus and cortex in animal models of diencephalic amnesia associated with thiamine deficiency. In the present study, the pyrithiamine-induced thiamine deficiency (PTD) rat model was used to assess the functional relationships between thalamic pathology, behavioral impairment, ACh efflux and cholinergic innervation of the hippocampus and cortex. In PTD-treated rats, ACh efflux during behavioral testing was blunted to differing degrees in the hippocampus, medial frontal cortex and the retrospenial cortex. In addition, significant reductions in cholinergic fiber densities were observed in each of those regions. However, only hippocampal cholinergic fiber density correlated significantly with ACh efflux in the same region suggesting that the reduction in cortical ACh efflux in cases of diencephalic amnesia cannot be fully explained by a loss of cholinergic fiber innervation. This notion supports the emerging theory that the functional consequences of the distal effects of lesions go beyond simple deafferentation. Specifically, some frontal cortical regions exhibit hypersensitivity to deafferentation that is only detected during behavioral and/or physiological demand.
Related Links	http://dx.doi.org/10.1111/j.1460-9568.2010.07358.x
Ending Page	858
Page Count	12
Starting Page	847
File Format	PDF
ISSN	0953816X
e-ISSN	14609568
Journal	The European journal of neuroscience
Issue Number	5
Volume Number	32
Language	English
Publisher Date	2010-09-01
Access Restriction	Open
Subject Keyword	Neuroscience(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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