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Epigenome manipulation as a pathway to new natural product scaffolds and their congeners
| Content Provider | PubMed Central |
|---|---|
| Author | Cichewicz, Robert H. |
| Abstract | The covalent modification of chromatin is an important control mechanism used by fungi to modulate the transcription of genes involved in secondary metabolite production. To date, both molecular-based and chemical approaches targeting histone and DNA posttranslational processes have shown great potential for rationally directing the activation and/or suppression of natural-product-encoding gene clusters. In this Highlight, the organization of the fungal epigenome is summarized and strategies for manipulating chromatin-related targets are presented. Applications of these techniques are illustrated using several recently published accounts in which chemical-epigenetic methods and mutant studies were successfully employed for the de novo or enhanced production of structurally diverse fungal natural products (e.g., anthraquinones, cladochromes, lunalides, mycotoxins, and nygerones). |
| Related Links | http://dx.doi.org/10.1039/b920860g |
| Ending Page | 22 |
| Page Count | 12 |
| Starting Page | 11 |
| File Format | |
| ISSN | 14604752 |
| e-ISSN | 14604752 |
| Journal | Natural product reports |
| Issue Number | 1 |
| Volume Number | 27 |
| Language | English |
| Publisher Date | 2010-01-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Biochemistry |
