NDLI: Wide genetic variation in the native pial collateral circulation is a major determinant of variation in severity of stroke

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Year: 2010, Volume: 30, Issue: 4

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Year: 2010, Volume: 30, Issue: 2

Year: 2010, Volume: 30, Issue: 1

Wide genetic variation in the native pial collateral circulation is a major determinant of variation in severity of stroke

Content Provider	PubMed Central
Author	Zhang, Hua Prabhakar, Pranay Sealock, Robert Faber, James E.
Copyright Year	2010
Abstract	Severity of stroke varies widely among individuals. Whether differences in the extent of the native (preexisting) pial collateral circulation exist and contribute to this variability is unknown. We addressed these questions and probed for potential genetic contributions using morphometric analysis of the collateral circulation in 15 inbred mouse strains recently shown to exhibit wide differences in infarct volume. Morphometrics were determined in the unligated left hemisphere (for native collaterals) and ligated right hemisphere (for remodeled collaterals) 6 days after permanent middle cerebral artery (MCA) occlusion. Variation among strains in native collateral number, diameter, MCA, anterior cerebral artery (ACA), and posterior cerebral artery (PCA) tree territories were, respectively: 56-fold, 3-fold, 42%, 56%, and 61%. Collateral length (P<0.001) and the number of penetrating arterioles branching from them also varied (P<0.05). Infarct volume correlated inversely with collateral number (P<0.0001), diameter (P<0.0001), and penetrating arteriole number (P<0.05) and directly with MCA territory (P<0.05). Relative collateral conductance and MCA territory, when factored together, strongly predicted infarct volume (P<0.0001). Outward remodeling of collaterals in the ligated hemisphere varied ∼3-fold. These data show that the extent of the native pial collateral circulation and collateral remodeling after obstruction vary widely with genetic background, and suggest that this variability, due to natural polymorphisms, is a major contributor to variability in infarct volume.
Related Links	http://dx.doi.org/10.1038/jcbfm.2010.10
Ending Page	934
Page Count	12
Starting Page	923
File Format	PDF
ISSN	0271678X
e-ISSN	15597016
Journal	Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Issue Number	5
Volume Number	30
Language	English
Publisher	Nature Publishing Group
Publisher Date	2010-05-01
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Neurology Clinical Neurology Cardiology and Cardiovascular Medicine Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical) Cardiology and Cardiovascular Medicine

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