NDLI: CD11c depletion severely disrupts Th2 induction and development in vivo

Content Provider	PubMed Central
Author	Phythian-adams, Alexander T. Cook, Peter C. Lundie, Rachel J. Jones, Lucy H. Smith, Katherine A. Barr, Tom A. Kristin, Hochweller Anderton, Stephen M. Hämmerling, Günter J. Maizels, Rick M. Macdonald, Andrew S.
Copyright Year	2010
Abstract	Although dendritic cells (DCs) are adept initiators of CD4+ T cell responses, their fundamental importance in this regard in Th2 settings remains to be demonstrated. We have used CD11c–diphtheria toxin (DTx) receptor mice to deplete CD11c+ cells during the priming stage of the CD4+ Th2 response against the parasitic helminth Schistosoma mansoni. DTx treatment significantly depleted CD11c+ DCs from all tissues tested, with 70–80% efficacy. Even this incomplete depletion resulted in dramatically impaired CD4+ T cell production of Th2 cytokines, altering the balance of the immune response and causing a shift toward IFN-γ production. In contrast, basophil depletion using Mar-1 antibody had no measurable effect on Th2 induction in this system. These data underline the vital role that CD11c+ antigen-presenting cells can play in orchestrating Th2 development against helminth infection in vivo, a response that is ordinarily balanced so as to prevent the potentially damaging production of inflammatory cytokines.
Related Links	http://dx.doi.org/10.1084/jem.20100734
Starting Page	2089
File Format	PDF
ISSN	15409538
e-ISSN	15409538
Journal	The Journal of Experimental Medicine
Issue Number	10
Volume Number	207
Language	English
Publisher	The Rockefeller University Press
Publisher Date	2010-09-27
Access Restriction	Open
Rights Holder	The Rockefeller University Press
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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