NDLI: B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance

Content Provider	PubMed Central
Author	Park, Jang-june Omiya, Ryusuke Matsumura, Yumiko Sakoda, Yukimi Kuramasu, Atsuo Augustine, Mathew M. Yao, Sheng Tsushima, Fumihiko Narazaki, Hidehiko Anand, Sudarshan Liu, Yingjia Strome, Scott E. Chen, Lieping Tamada, Koji
Abstract	T-cell tolerance is the central program that prevents harmful immune responses against self-antigens, in which inhibitory PD-1 signal given by B7-H1 interaction plays an important role. Recent studies demonstrated that B7-H1 binds CD80 besides PD-1, and B7-H1/CD80 interaction also delivers inhibitory signals in T cells. However, a role of B7-H1/CD80 signals in regulation of T-cell tolerance has yet to be explored. We report here that attenuation of B7-H1/CD80 signals by treatment with anti–B7-H1 monoclonal antibody, which specifically blocks B7-H1/CD80 but not B7-H1/PD-1, enhanced T-cell expansion and prevented T-cell anergy induction. In addition, B7-H1/CD80 blockade restored Ag responsiveness in the previously anergized T cells. Experiments using B7-H1 or CD80-deficient T cells indicated that an inhibitory signal through CD80, but not B7-H1, on T cells is responsible in part for these effects. Consistently, CD80 expression was detected on anergic T cells and further up-regulated when they were re-exposed to the antigen (Ag). Finally, blockade of B7-H1/CD80 interaction prevented oral tolerance induction and restored T-cell responsiveness to Ag previously tolerized by oral administration. Taken together, our findings demonstrate that the B7-H1/CD80 pathway is a crucial regulator in the induction and maintenance of T-cell tolerance.
Related Links	http://dx.doi.org/10.1182/blood-2010-01-265975
Ending Page	1298
Page Count	8
Starting Page	1291
File Format	PDF
ISSN	00064971
e-ISSN	15280020
Journal	Blood
Issue Number	8
Volume Number	116
Language	English
Publisher	American Society of Hematology
Publisher Date	2010-08-26
Access Restriction	Open
Rights Holder	American Society of Hematology
Subject Keyword	Immunology Cell Biology Biochemistry Hematology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Hematology Biochemistry Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy

Induction of type I IFN is required for overcoming tumor-specific T-cell tolerance after stem cell transplantation

Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction

Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance

B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells

STAT5 signaling is required for the efficient induction and maintenance of CML in mice

Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells

B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders

Interleukin-15 is not required for the induction or maintenance of orally induced peripheral tolerance

B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance

Similar Documents

Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy

Induction of type I IFN is required for overcoming tumor-specific T-cell tolerance after stem cell transplantation

Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction

Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance

B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells

STAT5 signaling is required for the efficient induction and maintenance of CML in mice

Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells

B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders

Interleukin-15 is not required for the induction or maintenance of orally induced peripheral tolerance

B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance