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| Content Provider | PubMed Central |
|---|---|
| Author | Zhu, He Jones, Craig K. Zijl, Peter C. M. Van Barker, Peter B. Zhou, Jinyuan |
| Abstract | Chemical exchange saturation transfer (CEST) MRI can detect low-concentration compounds with exchangeable protons through saturation transfer to water. CEST imaging is generally slow, as it requires acquisition of saturation images at multiple frequencies. In addition, multi-slice imaging is complicated by saturation effects differing from slice to slice because of relaxation losses. In this study, a fast three-dimensional (3D) CEST imaging sequence is presented that allows whole-brain coverage for a frequency-dependent saturation spectrum (z-spectrum, 26 frequencies) in less than 10 min. The approach employs a 3D gradient- and spin-echo (GRASE) readout using a prototype 32-channel phased-array coil, combined with two-dimensional SENSE accelerations. Results from a homogenous protein-containing phantom at 3T show that the sequence produced a uniform contrast across all slices. To show translational feasibility, scans were also performed on five healthy human subjects. Results for CEST images at 3.5ppm downfield of the water resonance, so-called amide proton transfer (APT) images, show that lipid signals are sufficiently suppressed and artifacts caused by B0 inhomogeneity can be removed in post-processing. The scan time and image quality of these in vivo results show that 3D CEST MRI using GRASE acquisition is feasible for whole-brain CEST studies at 3T in a clinical time frame. |
| Related Links | http://dx.doi.org/10.1002/mrm.22546 |
| Ending Page | 644 |
| Page Count | 7 |
| Starting Page | 638 |
| File Format | |
| ISSN | 07403194 |
| e-ISSN | 15222594 |
| Journal | Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine |
| Issue Number | 3 |
| Volume Number | 64 |
| Language | English |
| Publisher Date | 2010-09-01 |
| Access Restriction | Open |
| Subject Keyword | Radiology Nuclear Medicine and imaging Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging |
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