NDLI: Neutrophil kinetics in health and disease

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Neutrophil kinetics in health and disease

Content Provider	PubMed Central
Author	Summers, Charlotte Rankin, Sara M. Condliffe, Alison M. Singh, Nanak Peters, A. Michael Chilvers, Edwin R.
Copyright Year	2010
Abstract	Neutrophils play a key role in the elimination of pathogens. They are remarkably short-lived with a circulating half life of 6–8 h and hence are produced at a rate of 5 × 1010–10 × 1010 cells/day. Tight regulation of these cells is vital because they have significant histotoxic capacity and are widely implicated in tissue injury. This review outlines our current understanding of how neutrophils are released from the bone marrow; in particular, the role of the CXC chemokine receptor 4/stromal-derived factor 1 axis, the relative size and role of the freely circulating and marginated (i.e. slowly transiting) pools within the vascular compartment, and the events that result in the uptake and removal of circulating neutrophils. We also review current understanding of how systemic stress and inflammation affect this finely balanced system.
Related Links	http://dx.doi.org/10.1016/j.it.2010.05.006
Ending Page	324
Page Count	7
Starting Page	318
File Format	PDF
ISSN	14714906
e-ISSN	14714981
Journal	Trends in Immunology
Issue Number	8
Volume Number	31
Language	English
Publisher	Elsevier Science Ltd
Publisher Date	2010-08-01
Access Restriction	Open
Rights Holder	Elsevier Science Ltd
Subject Keyword	Immunology Immunology and Allergy Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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