NDLI: Why antibodies disobey the Hippocratic Oath and end up doing harm: a new clue

Content Provider	PubMed Central
Author	Pirofski, Liise-anne
Abstract	The appearance of methicillin-resistant Staphylococcus aureus (MRSA) as an endemic microbe, first in hospital and health care settings and more recently in the community, has led to a disastrous situation in which use of the available antibiotic armamentarium is increasingly ineffective and spawns further antibiotic resistance. This vicious cycle highlights the pressing need for an S. aureus vaccine. However, to date, clinical trials with S. aureus vaccines have not demonstrated sustained efficacy. In this issue of the JCI, Skurnik and colleagues report that specific antibodies to two different S. aureus surface polysaccharides, which independently promote effector cell killing of S. aureus in vitro and protection against S. aureus in animal models, bind to and abrogate the activity of one another when they are combined. This fascinating finding suggests a new paradigm to explain the failure of antibody immunity to S. aureus.
Related Links	http://dx.doi.org/10.1172/jci44312
Ending Page	3102
Page Count	4
Starting Page	3099
File Format	PDF
ISSN	00219738
e-ISSN	15588238
Journal	The Journal of Clinical Investigation
Issue Number	9
Volume Number	120
Language	English
Publisher	American Society for Clinical Investigation
Publisher Date	2010-09-01
Access Restriction	Open
Rights Holder	American Society for Clinical Investigation
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine

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Why antibodies disobey the Hippocratic Oath and end up doing harm: a new clue