NDLI: Regulation of dynamic polarity switching in bacteria by a Ras-like G-protein and its cognate GAP

Content Provider	PubMed Central
Author	Simone, Leonardy Mandy, Miertzschke Bulyha, Iryna Sperling, Eva Alfred, Wittinghofer Lotte, SÃ¸gaard-andersen
Copyright Year	2010
Abstract	The rod-shaped cells of the bacterium Myxococcus xanthus move uni-directionally and occasionally undergo reversals during which the leading/lagging polarity axis is inverted. Cellular reversals depend on pole-to-pole relocation of motility proteins that localize to the cell poles between reversals. We show that MglA is a Ras-like G-protein and acts as a nucleotide-dependent molecular switch to regulate motility and that MglB represents a novel GTPase-activating protein (GAP) family and is the cognate GAP of MglA. Between reversals, MglA/GTP is restricted to the leading and MglB to the lagging pole defining the leading/lagging polarity axis. For reversals, the Frz chemosensory system induces the relocation of MglA/GTP to the lagging pole causing an inversion of the leading/lagging polarity axis. MglA/GTP stimulates motility by establishing correct polarity of motility proteins between reversals and reversals by inducing their pole-to-pole relocation. Thus, the function of Ras-like G-proteins and their GAPs in regulating cell polarity is found not only in eukaryotes, but also conserved in bacteria.
Related Links	http://dx.doi.org/10.1038/emboj.2010.114
Ending Page	2289
Page Count	14
Starting Page	2276
File Format	PDF
ISSN	14602075
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	14
Volume Number	29
Language	English
Publisher	Nature Publishing Group
Publisher Date	2010-07-21
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

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