NDLI: Phenotyping the Right Ventricle in Patients with Pulmonary Hypertension

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Phenotyping the Right Ventricle in Patients with Pulmonary Hypertension

Content Provider	PubMed Central
Author	Simon, Marc A. Deible, Christopher Mathier, Michael A. Joan, Lacomis Goitein, Orly Shroff, Sanjeev G. Pinsky, Michael R.
Abstract	Right ventricular (RV) failure is associated with poor outcomes in pulmonary hypertension (PH). We sought to phenotype the RV in PH patients with compensated and decompensated RV function by quantifying regional and global RV structural and functional changes. Twenty-two patients (age 51 ± 11, 14 females, mean pulmonary artery (PA) pressure range 13–79 mmHg) underwent right heart catheterization, echocardiography, and ECG-gated multislice computed tomography of the chest. Patients were divided into three groups: Normal, PH with hemodynamically compensated, and decompensated RV function (PH-C and PH-D, respectively). RV wall thickness (WT) was measured at end-diastole (ED) and end-systole (ES) in three regions: infundibulum, lateral free wall, and inferior free wall. Globally, RV volumes progressively increased from Normal to PH-C to PH-D and RV ejection fraction decreased. Regionally, WT increased and fractional wall thickening (FWT) decreased in a spatially heterogeneous manner. Infundibular wall stress was elevated and FWT was lower regardless of the status of global RV function. In PH, there are significant phenotypic abnormalities in the RV even in the absence of overt hemodynamic RV decompensation. Regional changes in RV structure and function may be early markers of patients at risk for developing RV failure.
Related Links	http://dx.doi.org/10.1111/j.1752-8062.2009.00134.x
Ending Page	299
Page Count	6
Starting Page	294
File Format	PDF
ISSN	17528054
e-ISSN	17528062
Journal	Clinical and translational science
Issue Number	4
Volume Number	2
Language	English
Publisher Date	2009-08-01
Access Restriction	Open
Subject Keyword	Pharmacology, Toxicology and Pharmaceutics(all) Biochemistry, Genetics and Molecular Biology(all) Neuroscience(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Medicine Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics

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