NDLI: Complex Contributions of Ets2 to Craniofacial and Thymus Phenotypes of Trisomic “Down Syndrome” Mice

Content Provider	PubMed Central
Author	Hill, Cheryl A. Sussan, Thomas E. Reeves, Roger H. Richtsmeier, Joan T.
Abstract	Ts65Dn mice have segmental trisomy for orthologs of about half of the genes on human chromosome 21, including Ets2. These mice develop anomalies of the cranial skeleton and thymus that parallel those in Down syndrome. Over-expression of the Ets2 transcription factor gene was posited to be sufficient to produce these craniofacial and thymus deficits in transgenic mice that constitutively over-express a processed Ets2 transcript under a promiscuous promoter [Sumarsono et al., 1996; Wolvetang et al., 2003]. Evaluation of trisomic mice with varying copy numbers of a properly regulated Ets2 gene indicated increased dosage of Ets2 was not sufficient to produce effects on thymus and most of the cranial anomalies seen in Ts65Dn mice. However, mesoderm-derived cranial skeletal elements are significantly more affected in Ts65Dn, Ets2 +/− compared to Ts65Dn littermates suggesting a differential interaction of Ets2-related processes with mesoderm-derived and neural crest-derived formative tissues. Our results support the growing evidence for interactions among multiple genes contributing to developmental perturbations resulting in variation in complex DS phenotypes.
Related Links	http://dx.doi.org/10.1002/ajmg.a.33012
Ending Page	2165
Page Count	8
Starting Page	2158
File Format	PDF
ISSN	15524825
e-ISSN	15524833
Journal	American journal of medical genetics. Part A
Issue Number	10
Volume Number	149A
Language	English
Publisher Date	2009-10-01
Access Restriction	Open
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Complex contributions of Ets2 to craniofacial and thymus phenotypes of trisomic 'Down syndrome' mice.

Non-trisomic Homeobox Gene Expression during Craniofacial Development in the Ts65Dn Mouse Model of Down Syndrome

Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues

Trisomy for the Down syndrome ‘critical region’ is necessary but not sufficient for brain phenotypes of trisomic mice

Trisomic and Allelic Differences Influence Phenotypic Variability During Development of Down Syndrome Mice

Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome

A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions

The Phenotype of Persons Having Mosaicism for Trisomy 21/Down Syndrome Reflects the Percentage of Trisomic Cells Present in Different Tissues

Potential contribution of SIM2 and ETS2 functional polymorphisms in Down syndrome associated malignancies

Complex Contributions of Ets2 to Craniofacial and Thymus Phenotypes of Trisomic “Down Syndrome” Mice

Similar Documents

Complex contributions of Ets2 to craniofacial and thymus phenotypes of trisomic 'Down syndrome' mice.

Non-trisomic Homeobox Gene Expression during Craniofacial Development in the Ts65Dn Mouse Model of Down Syndrome

Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues

Trisomy for the Down syndrome ‘critical region’ is necessary but not sufficient for brain phenotypes of trisomic mice

Trisomic and Allelic Differences Influence Phenotypic Variability During Development of Down Syndrome Mice

Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome

A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions

The Phenotype of Persons Having Mosaicism for Trisomy 21/Down Syndrome Reflects the Percentage of Trisomic Cells Present in Different Tissues

Potential contribution of SIM2 and ETS2 functional polymorphisms in Down syndrome associated malignancies

Complex Contributions of Ets2 to Craniofacial and Thymus Phenotypes of Trisomic “Down Syndrome” Mice