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| Content Provider | PubMed Central |
|---|---|
| Author | Wu, Hui-chen Wang, Qiao Yang, Hwai-i Ahsan, Habibul Tsai, Wei-yann Wang, Li-yu Chen, Shu-yuan Chen, Chien-jen Santella, Regina M. |
| Copyright Year | 2008 |
| Abstract | To evaluate the role of oxidative stress and aflatoxin exposure on risk of hepatocellular carcinoma (HCC), a case–control study nested within a large community-based cohort was conducted in Taiwan. Baseline urine samples, collected from a total of 74 incident HCC cases and 290 matched controls, were used to determine by enzyme-linked immunosorbent assays the level of urinary 15-F2t-isoprostane (15-F2t-IsoP), a biomarker of lipid peroxidation. These samples had been previously analyzed for urinary aflatoxin B1 (AFB1) metabolites and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG). Pearson partial correlation coefficient analysis showed that urinary AFB1 metabolites and 8-oxodG were significantly associated with the level of urinary 15-F2t-IsoP. After adjustment for potential confounding factors in a conditional logistic regression model, urinary 15-F2t-IsoP was significantly associated with risk of HCC [above versus below the mean odds ratio (OR) = 2.53, 95% confidence interval (CI) = 1.30–4.93]. Moreover, when compared with subjects in the lowest tertile of 15-F2t-IsoP, there was a trend of increasing risk of HCC (P trend = 0.0008), with adjusted ORs (95% CIs) of 3.87 (1.32–11.38) and 6.27 (2.17–18.13) for the second and third tertile, respectively. In addition, the combination of urinary 15-F2t-IsoP above the mean and chronic hepatitis B virus (HBV) infection resulted in an OR of 19.01 (95% CI = 6.67–54.17) compared with those with low urinary 15-F2t-IsoP and without HBV infection. These results suggest that elevated levels of urinary 15-F2t-IsoP may be related to increasing level of aflatoxin exposure and are associated with an increased risk of HCC. |
| Related Links | http://dx.doi.org/10.1093/carcin/bgn057 |
| Ending Page | 976 |
| Page Count | 6 |
| Starting Page | 971 |
| File Format | |
| ISSN | 01433334 |
| e-ISSN | 14602180 |
| Journal | Carcinogenesis |
| Issue Number | 5 |
| Volume Number | 29 |
| Language | English |
| Publisher | Oxford University Press |
| Publisher Date | 2008-05-01 |
| Access Restriction | Open |
| Rights Holder | Oxford University Press |
| Subject Keyword | Cancer Research Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cancer Research |
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