NDLI: Effect of Heparin Oligomer Chain Length on the Activation of Valvular Interstitial Cells

Content Provider	PubMed Central
Author	Pedron, Sara Kasko, Andrea M. Peinado, Carmen Anseth, Kristi S.
Abstract	A key event in connective tissue remodeling involves the transformation of fibroblasts to myofibroblasts, also revealed by expression of α-smooth muscle actin (α-SMA). However, misregulation of this transition can lead to fibrosis, an overgrowth and hardening of tissue due to excess extracellular matrix deposition, a process that is linked to heart valve disease and many others. Both disease treatment and regenerative strategies would benefit from strategies for the controlled delivery and presentation of bioactive factors that can promote or suppress this transformation. In this regard, the ability of heparin to complex a plethora of growth factors offers a broad range of possibilities for this purpose. Here, the effects of heparin chain length and structure on valvular interstitial cell (VIC) phenotypic expression were explored. Heparin from porcine intestinal mucosa was depolymerized with heparinase and fractionated to obtain oligosaccharides of different sizes. VICs cultured with octasaccharides and decasaccharides exhibited higher expression of a-SMA when compared to other saccharides and full-length heparin. No activation of VICs was observed in response to full-length heparin presence in media.
Related Links	http://dx.doi.org/10.1021/bm100211k
Ending Page	1695
Page Count	4
Starting Page	1692
File Format	PDF
ISSN	15257797
e-ISSN	15264602
Journal	Biomacromolecules
Issue Number	6
Volume Number	11
Language	English
Publisher Date	2010-06-14
Access Restriction	Open
Subject Keyword	Materials Chemistry Bioengineering Polymers and Plastics Biomaterials Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Materials Chemistry Biomaterials Bioengineering Polymers and Plastics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Polymer Chain Length Effects on Fibroblast Attachment on Nylon-3-Modified Surfaces

Heparin mimicking polymer promotes myogenic differentiation of muscle progenitor cells

Poly(2-aminoethyl methacrylate) with well-defined chain-length for DNA vaccine delivery to dendritic cells

PEGylated Viral Nanoparticles (VNPs) for Biomedicine: the Impact of PEG Chain Length on VNP cell interactions in vitro and ex vivo

Effect of Alkyl Length of Peptide–Polymer Amphiphileon Cargo Encapsulation Stability and Pharmacokinetics of 3-HelixMicelles

The effect of sterilization on silk fibroin biomaterial properties

Effect of Hydration on Silk Film Material Properties

Elastin-like Peptide-Amphiphiles form nanofibers with tunable length

Analysis of PKR Activation Using Analytical Ultracentrifugation

Effect of Heparin Oligomer Chain Length on the Activation of Valvular Interstitial Cells

Similar Documents

Polymer Chain Length Effects on Fibroblast Attachment on Nylon-3-Modified Surfaces

Heparin mimicking polymer promotes myogenic differentiation of muscle progenitor cells

Poly(2-aminoethyl methacrylate) with well-defined chain-length for DNA vaccine delivery to dendritic cells

PEGylated Viral Nanoparticles (VNPs) for Biomedicine: the Impact of PEG Chain Length on VNP cell interactions in vitro and ex vivo

Effect of Alkyl Length of Peptide–Polymer Amphiphileon Cargo Encapsulation Stability and Pharmacokinetics of 3-HelixMicelles

The effect of sterilization on silk fibroin biomaterial properties

Effect of Hydration on Silk Film Material Properties

Elastin-like Peptide-Amphiphiles form nanofibers with tunable length

Analysis of PKR Activation Using Analytical Ultracentrifugation

Effect of Heparin Oligomer Chain Length on the Activation of Valvular Interstitial Cells