NDLI: Brain atrophy associated with baseline and longitudinal measures of cognition

Content Provider	PubMed Central
Author	Cardenas, V. A. Chao, L. L. Studholme, C. Yaffe, K. Miller, B. L. Madison, C. Buckley, S. T. Mungas, D. Schuff, N. Weiner, M. W.
Abstract	The overall goal was to identify patterns of brain atrophy associated with cognitive impairment and future cognitive decline in non-demented elders. Seventy-one participants were studied with structural MRI and neuropsychological testing at baseline and 1 year follow-up. Deformation-based morphometry was used to examine the relationship between regional baseline brain tissue volume with baseline and longitudinal measures of delayed verbal memory, semantic memory, and executive function. Smaller right hippocampal and entorhinal cortex (ERC) volumes at baseline were associated with worse delayed verbal memory performance at baseline while smaller left ERC volume was associated with greater longitudinal decline. Smaller left superior temporal cortex at baseline was associated with worse semantic memory at baseline, while smaller left temporal white and gray matter volumes were associated with greater semantic memory decline. Increased CSF and smaller frontal lobe volumes were associated with impaired executive function at baseline and greater longitudinal executive decline. These findings suggest that baseline volumes of prefrontal and temporal regions may underlie continuing cognitive decline due to aging, pathology, or both in non-demented elderly individuals.
Related Links	http://dx.doi.org/10.1016/j.neurobiolaging.2009.04.011
Ending Page	580
Page Count	9
Starting Page	572
File Format	PDF
ISSN	01974580
e-ISSN	15581497
Journal	Neurobiology of aging
Issue Number	4
Volume Number	32
Language	English
Publisher Date	2011-04-01
Access Restriction	Open
Subject Keyword	Developmental Biology Ageing Neuroscience(all) Geriatrics and Gerontology Clinical Neurology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Developmental Biology Aging Neurology (clinical) Geriatrics and Gerontology

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