NDLI: Cystatin C is released in association with exosomes: a new tool of neuronal communication which is unbalanced in Alzheimer’s Disease

Content Provider	PubMed Central
Author	Ghidoni, Roberta Paterlini, Anna Albertini, Valentina Glionna, Michela Monti, Eugenio Luisa, Schiaffonati Benussi, Luisa Levy, Efrat Binetti, Giuliano
Copyright Year	2009
Abstract	It has recently become clear that proteins associated with neurodegenerative disorders can be selectively incorporated into intraluminal vesicles of multivesicular bodies and subsequently released within exosomes. Multiple lines of research support a neuroprotective role for cystatin C in Alzheimer’s disease (AD). Herein we demonstrate that cystatin C, a protein targeted to the classical secretory pathway by its signal peptide sequence, is also secreted by mouse primary neurons in association with exosomes. Immunoproteomic analysis using SELDI TOF MS revealed the presence in exosomes of at least 9 different cystatin C glycoforms. Moreover, the over-expression of familial AD-associated presenilin 2 mutations (PS2 M239I and PS2 T122R) resulted in reduced levels of all cystatin C forms (native and glycosylated) and of amyloid-β precursor protein (APP) metabolites within exosomes. A better understanding of the mechanisms involved in exosomal processing and release may have important implications for the fight against AD and other neurodegenerative diseases.
Related Links	http://dx.doi.org/10.1016/j.neurobiolaging.2009.08.013
Ending Page	1442
Page Count	8
Starting Page	1435
File Format	PDF
ISSN	01974580
e-ISSN	15581497
Journal	Neurobiology of aging
Issue Number	8
Volume Number	32
Language	English
Publisher Date	2011-08-01
Access Restriction	Open
Subject Keyword	Developmental Biology Ageing Neuroscience(all) Geriatrics and Gerontology Clinical Neurology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Developmental Biology Aging Neurology (clinical) Geriatrics and Gerontology

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