NDLI: H2S mediates O2 sensing in the carotid body

Content Provider	PubMed Central
Author	Peng, Ying-jie Nanduri, Jayasri Raghuraman, Gayatri Souvannakitti, Dangjai Gadalla, Moataz M. Kumar, Ganesh K. Snyder, Solomon H. Prabhakar, Nanduri R.
Abstract	Gaseous messengers, nitric oxide and carbon monoxide, have been implicated in O2 sensing by the carotid body, a sensory organ that monitors arterial blood O2 levels and stimulates breathing in response to hypoxia. We now show that hydrogen sulfide (H2S) is a physiologic gasotransmitter of the carotid body, enhancing its sensory response to hypoxia. Glomus cells, the site of O2 sensing in the carotid body, express cystathionine γ-lyase (CSE), an H2S-generating enzyme, with hypoxia increasing H2S generation in a stimulus-dependent manner. Mice with genetic deletion of CSE display severely impaired carotid body response and ventilatory stimulation to hypoxia, as well as a loss of hypoxia-evoked H2S generation. Pharmacologic inhibition of CSE elicits a similar phenotype in mice and rats. Hypoxia-evoked H2S generation in the carotid body seems to require interaction of CSE with hemeoxygenase-2, which generates carbon monoxide. CSE is also expressed in neonatal adrenal medullary chromaffin cells of rats and mice whose hypoxia-evoked catecholamine secretion is greatly attenuated by CSE inhibitors and in CSE knockout mice.
Related Links	http://dx.doi.org/10.1073/pnas.1005866107
Ending Page	10724
Page Count	6
Starting Page	10719
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	107
Language	English
Publisher	National Academy of Sciences
Publisher Date	2010-06-08
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema

Reply to Olson and Perry: H2S physiologically mediates O2 sensing

H2S and O2 sensing

H2S, a gasotransmitter for oxygen sensing in carotid body. Focus on 'Endogenous H2S is required for hypoxic sensing by carotid body glomus cells'.

Gasotransmitter Regulation of Ion Channels: A Key Step in O2 Sensing By the Carotid Body

Endogenous H2S is required for hypoxic sensing by carotid body glomus cells

CARBON MONOXIDE (CO) AND HYDROGEN SULFIDE (H2S) IN HYPOXIC SENSING BY THE CAROTID BODY

Fluoresceinated Peanut Agglutinin (PNA) is a Marker for Live O2 Sensing Glomus Cells in Rat Carotid Body

Are Multiple Mitochondrial Related Signalling Pathways Involved in Carotid Body Oxygen Sensing?

H2S mediates O2 sensing in the carotid body

Similar Documents

Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema

Reply to Olson and Perry: H2S physiologically mediates O2 sensing

H2S and O2 sensing

H2S, a gasotransmitter for oxygen sensing in carotid body. Focus on 'Endogenous H2S is required for hypoxic sensing by carotid body glomus cells'.

Gasotransmitter Regulation of Ion Channels: A Key Step in O2 Sensing By the Carotid Body

Endogenous H2S is required for hypoxic sensing by carotid body glomus cells

CARBON MONOXIDE (CO) AND HYDROGEN SULFIDE (H2S) IN HYPOXIC SENSING BY THE CAROTID BODY

Fluoresceinated Peanut Agglutinin (PNA) is a Marker for Live O2 Sensing Glomus Cells in Rat Carotid Body

Are Multiple Mitochondrial Related Signalling Pathways Involved in Carotid Body Oxygen Sensing?

H2S mediates O2 sensing in the carotid body